Lupeol and amphotericin B mediate synergistic anti-leishmanial immunomodulatory effects in Leishmania donovani-infected BALB/c mice.
Sign Up to like & getrecommendations! Published in 2020 at "Cytokine"
DOI: 10.1016/j.cyto.2020.155319
Abstract: Leishmania donovani, a protozoan parasite, inflicts the disease Visceral leishmaniasis (VL) Worldwide. The only orally bioavailable drug miltefosine is toxic, whereas liposomal amphotericin B (AmpB) is expensive. Lupeol, a triterpenoid from Sterculia villosa bark, was… read more here.
Keywords: leishmanial immunomodulatory; anti leishmanial; lupeol; immunomodulatory effects ... See more keywords
Quantitative monitoring of experimental and human leishmaniasis employing amastigote-specific genes
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DOI: 10.1017/s0031182022000610
Abstract: Abstract Abstract The gold standard for diagnosis of leishmaniasis is the microscopic detection of amastigotes/Leishman Donovan (LD) bodies, but its moderate sensitivity necessitates the development of molecular approaches. This study aimed to quantify in experimental… read more here.
Keywords: donovani infected; monitoring; amastigote specific; leishmaniasis ... See more keywords
Retinoic Acid Increases Cellular Cholesterol in Leishmania donovani-Infected Macrophages in an mTOR-Independent Manner
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DOI: 10.1128/spectrum.02699-22
Abstract: People who reside in regions where leishmaniasis is endemic and who lack proteins, iron, zinc, and vitamin A in their diet are more prone to develop visceral leishmaniasis (VL) as a full-blown disease. Vitamin A… read more here.
Keywords: donovani infected; leishmania donovani; cholesterol; mtor ... See more keywords
Modulation of TLR4 Sialylation Mediated by a Sialidase Neu1 and Impairment of Its Signaling in Leishmania donovani Infected Macrophages
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DOI: 10.3389/fimmu.2019.02360
Abstract: Altered sialylation is generally maintained by a fine balance between sialidases and sialyltransferases, which plays an essential role during disease pathogenesis. TLR4 is a membrane-bound highly sialylated glycoprotein predominantly having α2,3-linked sialic acids. It is… read more here.
Keywords: modulation tlr4; infected macrophages; sialylation; donovani infected ... See more keywords