Recent advances in understanding Leishmania donovani infection: The importance of diverse host regulatory pathways
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DOI: 10.1002/iub.1759
Abstract: Invasion of host cell by pathogens induce various intracellular signalling pathways. The host cell through the initiation of these signalling circuits desperately wants to get rid of the pathogen, whereas the pathogen tries to subvert… read more here.
Keywords: understanding leishmania; donovani infection; advances understanding; recent advances ... See more keywords
Ly6Chi inflammatory monocytes promote susceptibility to Leishmania donovani infection
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DOI: 10.1038/s41598-017-14935-3
Abstract: Ly6Chi inflammatory monocytes (iMO) are critical for host defense against toxoplasmosis and malaria but their role in leishmaniasis is unclear. In this study, we report a detrimental role of Ly6Chi iMOs in visceral leishmaniasis (VL)… read more here.
Keywords: ly6chi imos; inflammatory monocytes; donovani infection; ly6chi inflammatory ... See more keywords
Activation of neutrophils excels the therapeutic potential of Mycobacterium indicus pranii and heat‐induced promastigotes against antimony‐resistant Leishmania donovani infection
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DOI: 10.1111/sji.13350
Abstract: Repurposing drugs and adjuvants is an attractive choice of present therapy that reduces the substantial costs, chances of failure, and systemic toxicity. Mycobacterium indicus pranii was originally developed as a leprosy vaccine but later has… read more here.
Keywords: leishmania; infection; indicus pranii; donovani infection ... See more keywords
Prevalence of asymptomatic Leishmania donovani infection and associated factors in Ethiopia: a systematic review and meta-analysis
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DOI: 10.1186/s12879-024-10275-6
Abstract: Visceral leishmaniasis is endemic in Ethiopia and caused by Leishmania donovani. Although the disease manifests with significant clinical variability, a substantial number of individuals are asymptomatic. These individuals can serve as reservoirs, complicating control efforts.… read more here.
Keywords: meta; donovani; donovani infection; analysis ... See more keywords
Sphingosine-1-phosphate signaling in Leishmania donovani infection in macrophages
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DOI: 10.1371/journal.pntd.0006647
Abstract: Background Sphingosine-1-phosphate (S1P) is a crucial regulator of a wide array of cellular processes, such as apoptosis, cell proliferation, migration, and differentiation, but its role in Leishmania donovani infection is unknown. Methodology/ principal findings In… read more here.
Keywords: donovani infection; infection; sphingosine phosphate; leishmania donovani ... See more keywords
Leishmania Infection-Induced Proteolytic Processing of SIRPα in Macrophages
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DOI: 10.3390/pathogens12040593
Abstract: The shedding of cell surface receptors may bring synergistic outcomes through the loss of receptor-mediated cell signaling and competitive binding of the shed soluble receptor to its ligand. Thus, soluble receptors have both biological importance… read more here.
Keywords: infection induced; donovani infection; infection; sirp ... See more keywords