7-Methoxyderivative of tacrine is a ‘foot-in-the-door’ open-channel blocker of GluN1/GluN2 and GluN1/GluN3 NMDA receptors with neuroprotective activity in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.08.010
Abstract: Abstract N‐methyl‐d‐aspartate receptors (NMDARs) are ionotropic glutamate receptors that mediate excitatory neurotransmission in the mammalian central nervous system (CNS), and their dysregulation results in the aetiology of many CNS syndromes. Several NMDAR modulators have been… read more here.
Keywords: door open; open channel; glun1; meota ... See more keywords
Now that the door is open: an update on ischemic stroke pharmacotherapeutics for the neurointerventionalist.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurointerventional surgery"
DOI: 10.1136/jnis-2022-019293
Abstract: The last 10 years have seen a major shift in management of large vessel ischemic stroke with changes towards ever-expanding use of reperfusion therapies (intravenous thrombolysis and mechanical thrombectomy). These strategies 'open the door' to… read more here.
Keywords: open update; door open; update ischemic; stroke ... See more keywords