Poly-Catecholic Functionalization of Biomolecules for Rapid Gelation, Robust Injectable Bioadhesion, and Near-Infrared Responsiveness.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203404
Abstract: Mussel-inspired catechol-functionalization of degradable natural biomaterials such as gelatin has garnered significant interest as an approach to achieve bioadhesion for sutureless wound closure. However, conjugation capacity in standard coupling reactions such as carbodiimide chemistry is… read more here.
Keywords: bioadhesion; gelation; functionalization; near infrared ... See more keywords
Mussel‐Glue Inspired Adhesives: A Study on the Relevance of l ‐Dopa and the Function of the Sequence at Nanomaterial‐Peptide Interfaces
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Materials Interfaces"
DOI: 10.1002/admi.201900501
Abstract: Mussel glue‐proteins undergo structural transitions at material interfaces to optimize adhesive surface contacts. Those intriguing structure responses are mimicked by a mussel‐glue mimetic peptide (HSY*SGWSPY*RSG (Y* = l‐Dopa)) that was previously selected by phage‐display to… read more here.
Keywords: peptide; full length; surface contacts; dopa ... See more keywords
Covalent Functionalization of PMMA Surface with L‐3,4‐Dihydroxyphenylalanine (L‐DOPA) to Enhance its Biocompatibility and Adhesion to Corneal Tissue
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Materials Interfaces"
DOI: 10.1002/admi.201900767
Abstract: The Boston keratoprosthesis (B‐KPro) is globally the most commonly implanted artificial cornea for patients with severe corneal diseases, particularly those with multiple allograft failures. Despite providing a good visual recovery, the poor adhesion between the… read more here.
Keywords: corneal; pmma; biocompatibility; surface ... See more keywords
Levodopa: A new look at an old friend
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.27216
Abstract: Levodopa is the most effective antiparkinsonian agent, but chronic treatment is associated with the development of motor complications in the majority of patients with PD. Recent scientific and clinical advances are improving this situation. Long‐term,… read more here.
Keywords: look old; motor complications; levodopa new; new look ... See more keywords
A Homozygous Splicing Mutation in PDE2A in a Family With Atypical Rett Syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Movement Disorders"
DOI: 10.1002/mds.28023
Abstract: UPDRS-III with dyskinesia (Supporting Information Table S1). However, she developed FOG on gait initiation, straight walking, doorways, and turning. FOG was associated with rising up onto the toes during straight walking and onto the toe… read more here.
Keywords: infusion; dopa; fog; rate ... See more keywords
Monoamine oxidase A inhibition with moclobemide enhances the anti-parkinsonian effect of L-DOPA in the MPTP-lesioned marmoset
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-020-01933-y
Abstract: Whereas monoamine oxidase (MAO) type B inhibitors are used as adjunct to L-3,4-dihydroxyphenylalanine (L-DOPA) in the treatment of Parkinson’s disease (PD), the enzyme MAO type A (MAO-A) also participates in the metabolism of dopamine in… read more here.
Keywords: mptp lesioned; mao; moclobemide; dopa ... See more keywords
68Ga-DOTANOC and 18F-DOPA PET/CT: a site-specific approach to the imaging of parangliomas of the head and neck and of the abdomen
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-019-04299-3
Abstract: Maximum intensity projection and transaxial GaDOTANOC (a–d) and F-DOPA (e–h) PET/CT images in a patient with SDHD mutation-related paragangliomas (PGL) and otherwise unexplained and uncontrolled hypertension are shown. Three PGL in the head and neck… read more here.
Keywords: dopa; dopa pet; head neck;
Serotonergic targets for the treatment of l-DOPA-induced dyskinesia
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-017-1837-1
Abstract: Dopamine (DA) replacement therapy with l-3,4-dihydroxyphenylalanine (l-DOPA) continues to be the gold-standard treatment for Parkinson’s disease (PD). Despite clear symptomatic benefit, long-term l-DOPA use often results in the development of l-DOPA-induced dyskinesia (LID), significantly reducing… read more here.
Keywords: targets treatment; treatment; serotonergic targets; dopa ... See more keywords
Impact of the catechol-O-methyltransferase Val158Met polymorphism on the pharmacokinetics of l-dopa and its metabolite 3-O-methyldopa in combination with entacapone
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-020-02267-y
Abstract: In the pharmacotherapy of patients with Parkinson’s disease (PD), entacapone reduces the peripheral metabolism of l-dopa to 3-O-methyldopa (3-OMD), thereby prolonging the half-life (t1/2) of l-dopa and increasing the area under the concentration curve (AUC).… read more here.
Keywords: catechol methyltransferase; val158met polymorphism; dopa; entacapone ... See more keywords
Acute motor axonal polyneuropathy in one parkinsonian patient receiving moderate dosage of oral levodopa
Sign Up to like & getrecommendations! Published in 2021 at "Neurological Sciences"
DOI: 10.1007/s10072-020-04989-z
Abstract: Recently, increased attention has been given to polyneuropathy in Parkinson’s disease (PD), with a possible causative role of levodopa (L-dopa) metabolic pathway [1, 2]. Oral L-dopa was mostly associated with a large predominance of slowly… read more here.
Keywords: dopa; motor; parkinsonian patient; dosage ... See more keywords
Immobilized Peptide on the Surface of Poly l-DOPA/Silica for Targeted Delivery of 5-Fluorouracil to Breast Tumor
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-019-09834-2
Abstract: Chemotherapy using drug delivery systems can target tumor cells selectively and do not affect normal cells. In this paper, a specific drug delivery system with immobilized NL2 peptide on the surface of polymeric nano drug… read more here.
Keywords: breast; delivery; peptide surface; drug ... See more keywords