Motor progression and nigrostriatal neurodegeneration in Parkinson's disease.
Sign Up to like & getrecommendations! Published in 2022 at "Annals of neurology"
DOI: 10.1002/ana.26373
Abstract: OBJECTIVE The motor severity in Parkinson's disease (PD) is believed to parallel with dopaminergic terminal degeneration in the striatum although the terminal was reported to be virtually absent by 4 years post-diagnosis. Meanwhile, neuromelanin-laden dopamine neuron… read more here.
Keywords: dopamine; dopamine neuron; parkinson disease; loss ... See more keywords
Heterogeneity in Dopamine Neuron Synaptic Actions Across the Striatum and Its Relevance for Schizophrenia
Sign Up to like & getrecommendations! Published in 2017 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2016.07.002
Abstract: Brain imaging has revealed alterations in dopamine uptake, release, and receptor levels in patients with schizophrenia that have been resolved on the scale of striatal subregions. However, the underlying synaptic mechanisms are on a finer… read more here.
Keywords: across striatum; neuron; synaptic actions; dopamine neuron ... See more keywords
Transplantation site influences the phenotypic differentiation of dopamine neurons in ventral mesencephalic grafts in Parkinsonian rats
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2017.01.010
Abstract: Abstract Foetal midbrain progenitors have been shown to survive, give rise to different classes of dopamine neurons and integrate into the host brain alleviating Parkinsonian symptoms following transplantation in patients and animal models of the… read more here.
Keywords: dopamine; transplantation site; dopamine neuron; dopamine neurons ... See more keywords
Role of aromatase and radial glial cells in neurotoxin-induced dopamine neuron degeneration and regeneration.
Sign Up to like & getrecommendations! Published in 2017 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2016.02.011
Abstract: Radial glial cells (RGCs) in teleost brain are progenitor cells that express aromatase B and produce estrogens. Controversial data suggest that estrogens are critical for brain repair and neurogenesis in teleosts. Using a goldfish model… read more here.
Keywords: radial glial; glial cells; neurotoxin induced; aromatase ... See more keywords
State-dependent effects of the D2 partial agonist aripiprazole on dopamine neuron activity in the MAM neurodevelopmental model of schizophrenia
Sign Up to like & getrecommendations! Published in 2018 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-018-0219-1
Abstract: Aripiprazole is an antipsychotic drug characterized by partial agonist activity at D2 receptors to normalize both hyperdopaminergic and hypodopaminergic states. Traditional D2 antagonist antipsychotic drugs have been shown previously to reduce dopamine neuron activity through… read more here.
Keywords: dopamine neuron; depolarization block; activity;
Orexin receptor antagonists reverse aberrant dopamine neuron activity and related behaviors in a rodent model of stress-induced psychosis
Sign Up to like & getrecommendations! Published in 2021 at "Translational Psychiatry"
DOI: 10.1038/s41398-021-01235-8
Abstract: Post-traumatic stress disorder (PTSD) is a prevalent condition affecting approximately 8% of the United States population and 20% of United States combat veterans. In addition to core symptoms of the disorder, up to 64% of… read more here.
Keywords: orexin; activity; dopamine neuron; orexin receptor ... See more keywords
Dopamine neuron induction and the neuroprotective effects of thyroid hormone derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-49876-6
Abstract: Parkinson’s disease (PD) is a neurodegenerative disease characterized by progressive movement disturbances caused by the selective loss of dopamine (DA) neurons in the substantia nigra. Despite the identification of the causal mechanisms underlying the pathogenesis… read more here.
Keywords: hormone; hormone derivatives; dopamine neuron; thyroid hormone ... See more keywords
Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson's disease.
Sign Up to like & getrecommendations! Published in 2022 at "Science advances"
DOI: 10.1126/sciadv.abh1824
Abstract: Mutations in PINK1 and parkin highlight the mitochondrial axis of Parkinson's disease (PD) pathogenesis. PINK1/parkin regulation of the transcriptional repressor PARIS bears direct relevance to dopamine neuron survival through augmentation of PGC-1α-dependent mitochondrial biogenesis. Notably,… read more here.
Keywords: dopamine neuron; neuron survival; paris;
Neuropeptide-Y alters VTA dopamine neuron activity through both pre- and postsynaptic mechanisms.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of neurophysiology"
DOI: 10.1152/jn.00879.2016
Abstract: The mesocorticolimbic dopamine system, the brain's reward system, regulates many different behaviors including food intake, food reward, and feeding-related behaviors, and there is increasing evidence that hypothalamic feeding-related neuropeptides alter dopamine neuron activity to affect… read more here.
Keywords: neuron activity; activity; dopamine neuron; dopamine neurons ... See more keywords
Gestational Buprenorphine Exposure Disrupts Dopamine Neuron Activity and Related Behaviors in Adulthood
Sign Up to like & getrecommendations! Published in 2022 at "eNeuro"
DOI: 10.1523/eneuro.0499-21.2022
Abstract: Abstract Opioid misuse among pregnant women is rapidly increasing in the United States. The number of maternal opioid-related diagnoses increased by 131% in the last 10 years, resulting in an increased number of infants exposed… read more here.
Keywords: neuron activity; dopamine neuron; gestational buprenorphine; buprenorphine ... See more keywords
Histamine Modulates Midbrain Dopamine Neuron Differentiation Through the Regulation of Epigenetic Marks
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00215
Abstract: During midbrain development, dopamine neuron differentiation occurs before birth. Epigenetic processes such as DNA methylation and demethylation as well as post-translational modification of histones occur during neurogenesis. Here, we administered histamine (HA) into the brain… read more here.
Keywords: dopamine neuron; histamine modulates; neuron differentiation; modulates midbrain ... See more keywords