Synaptic signalling in a network of dopamine neurons: what prevents proper intercellular crosstalk?
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13910
Abstract: Human embryonic stem cell (hESC)‐derived midbrain dopamine (DA) neurons stand out as a cell source for transplantation with their sustainability and consistency superior to the formerly used fetal tissues. However, multiple studies of DA neurons… read more here.
Keywords: synaptic signalling; signalling network; crosstalk; neurons prevents ... See more keywords
p70S6K on astrocytes protects dopamine neurons from 1‐methyl‐4‐phenylpyridinium neurotoxicity
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24013
Abstract: Our recent finding has demonstrated that astrocytes confer neuroprotection by endogenously producing ciliary neurotrophic factor (CNTF) via transient receptor potential vanilloid 1 (TRPV1) in Parkinson's disease (PD). In this study, the possible molecular target for… read more here.
Keywords: trpv1; p70s6k signaling; p70s6k astrocytes; p70s6k ... See more keywords
Morpho‐Functional Changes of Nigral Dopamine Neurons in an α‐Synuclein Model of Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders"
DOI: 10.1002/mds.29269
Abstract: The accumulation of α‐synuclein (α‐syn) fibrils in intraneuronal inclusions called Lewy bodies and Lewy neurites is a pathological signature of Parkinson's disease (PD). Although several aspects linked to α‐syn–dependent pathology (concerning its spreading, aggregation, and… read more here.
Keywords: dopamine neurons; parkinson disease; functional changes; morpho functional ... See more keywords
Activation of ventral tegmental area dopamine neurons produces wakefulness through dopamine D2-like receptors in mice
Sign Up to like & getrecommendations! Published in 2017 at "Brain Structure and Function"
DOI: 10.1007/s00429-017-1365-7
Abstract: A growing body of evidence suggests that dopamine plays a role in sleep–wake regulation, but the dopamine-producing brain areas that control sleep–wake states are unclear. In this study, we chemogenetically activated dopamine neurons in the… read more here.
Keywords: wakefulness; tegmental area; dopamine; ventral tegmental ... See more keywords
Salusin-β mediate neuroprotective effects for Parkinson's disease.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.07.059
Abstract: Neuropeptides, small peptides found in many mammalian brain, play key roles in communicating with each other to modulate neuronal activity. Here, we reported that endogenous neuropeptide salusin-β has neuroprotective effects on the midbrain dopamine neurons… read more here.
Keywords: midbrain dopamine; salusin; neuroprotective effects; parkinson disease ... See more keywords
Projection-Target-Defined Effects of Orexin and Dynorphin on VTA Dopamine Neurons.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.01.030
Abstract: Circuit-specific signaling of ventral tegmental area (VTA) dopamine neurons drives different aspects of motivated behavior, but the neuromodulatory control of these circuits is unclear. We tested the actions of co-expressed lateral hypothalamic peptides, orexin A… read more here.
Keywords: projection target; dopamine neurons; vta dopamine;
Dorsal Raphe Dual Serotonin-Glutamate Neurons Drive Reward by Establishing Excitatory Synapses on VTA Mesoaccumbens Dopamine Neurons
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.01.014
Abstract: SUMMARY Dorsal raphe (DR) serotonin neurons provide a major input to the ventral tegmental area (VTA). Here, we show that DR serotonin transporter (SERT) neurons establish both asymmetric and symmetric synapses on VTA dopamine neurons,… read more here.
Keywords: synapses vta; serotonin; mesoaccumbens dopamine; dorsal raphe ... See more keywords
Sox6 expression distinguishes dorsally and ventrally biased dopamine neurons in the substantia nigra with distinctive properties and embryonic origins
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109975
Abstract: SUMMARY Dopamine (DA) neurons in the ventral tier of the substantia nigra pars compacta (SNc) degenerate prominently in Parkinson’s disease, while those in the dorsal tier are relatively spared. Defining the molecular, functional, and developmental… read more here.
Keywords: sox6 expression; substantia nigra; dopamine neurons; expression distinguishes ... See more keywords
Dopamine D3 and acetylcholine nicotinic receptor heteromerization in midbrain dopamine neurons: Relevance for neuroplasticity
Sign Up to like & getrecommendations! Published in 2017 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.01.015
Abstract: Activation of nicotinic acetylcholine receptors (nAChR) promotes the morphological remodeling of cultured dopamine (DA) neurons, an effect requiring functional DA D3 receptors (D3R). The aim of this study was to investigate the mechanisms mediating D3R-nAChR… read more here.
Keywords: interfering peptides; dopamine acetylcholine; dopamine neurons; d3r nachr ... See more keywords
Acute and subchronic PCP attenuate D2 autoreceptor signaling in substantia nigra dopamine neurons
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2019.01.108
Abstract: Phencyclidine (PCP) administration is commonly used to model schizophrenia in laboratory animals. While PCP is well-characterized as an antagonist of glutamate-sensitive N-methyl-D-aspartate (NMDA) receptors, its effects on dopamine signaling are not well understood. Here we… read more here.
Keywords: autoreceptor; nigra dopamine; dopamine; substantia nigra ... See more keywords
Transplantation site influences the phenotypic differentiation of dopamine neurons in ventral mesencephalic grafts in Parkinsonian rats
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2017.01.010
Abstract: Abstract Foetal midbrain progenitors have been shown to survive, give rise to different classes of dopamine neurons and integrate into the host brain alleviating Parkinsonian symptoms following transplantation in patients and animal models of the… read more here.
Keywords: dopamine; transplantation site; dopamine neuron; dopamine neurons ... See more keywords