Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it: a translational imaging study with ketamine
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DOI: 10.1038/s41380-020-0740-6
Abstract: Patients with schizophrenia show increased striatal dopamine synthesis capacity in imaging studies. The mechanism underlying this is unclear but may be due to N-methyl-D-aspartate receptor (NMDAR) hypofunction and parvalbumin (PV) neuronal dysfunction leading to disinhibition… read more here.
Keywords: sub chronic; synthesis capacity; ketamine; dopamine ... See more keywords