Dopamine D1 + D3 receptor density may correlate with parkinson disease clinical features
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51274
Abstract: Dopamine D2‐like receptors – mainly dopamine D2 receptors (D2R) and dopamine D3 receptors (D3R) – are believed to be greatly involved in the pathology of Parkinson disease (PD) progression. However, these receptors have not been… read more here.
Keywords: receptor density; dopamine receptors; disease; parkinson disease ... See more keywords
The passive avoidance task ameliorate the toxic effects of bisphenol A on dopamine D1 receptor density in hippocampus, amygdala, and cerebellum of male rats
Sign Up to like & getrecommendations! Published in 2023 at "Brain and Behavior"
DOI: 10.1002/brb3.2942
Abstract: Dopamine D1 receptor seems to play a role in mediating plasticity. Therefore, the present study aimed to investigate the effects of passive avoidance tasks postexposed to BPA on dopamine D1 receptor density in the hippocampus,… read more here.
Keywords: dopamine receptor; passive avoidance; density hippocampus; receptor ... See more keywords
Safety, Tolerability, and Pharmacokinetics of Mevidalen (LY3154207), a Centrally Acting Dopamine D1 Receptor-Positive Allosteric Modulator, in Patients With Parkinson Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1039
Abstract: Mevidalen (LY3154207) is a positive allosteric modulator of the dopamine D1 receptor that enhances the affinity of dopamine for the D1 receptor. The safety, tolerability, motor effects, and pharmacokinetics of mevidalen were studied in patients… read more here.
Keywords: dopamine receptor; patients parkinson; mevidalen; parkinson disease ... See more keywords
Safety, Tolerability, and Pharmacokinetics of Mevidalen (LY3154207), a Centrally Acting Dopamine D1 Receptor‐Positive Allosteric Modulator (D1PAM), in Healthy Subjects
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.874
Abstract: Activation of the brain dopamine D1 receptor has attracted attention because of its promising role in neuropsychiatric diseases. Although efforts to develop D1 agonists have been challenging, a positive allosteric modulator (PAM), represents an attractive… read more here.
Keywords: allosteric modulator; mevidalen ly3154207; healthy subjects; dopamine receptor ... See more keywords
The impact of dopamine receptor D4, temperamental negativity, and household chaos on young twins' externalizing behaviors.
Sign Up to like & getrecommendations! Published in 2023 at "Developmental psychobiology"
DOI: 10.1002/dev.22387
Abstract: Biological and genetic factors, as well as contextual influences, contribute to the etiology of externalizing behaviors in children and adolescents. The current project used a longitudinal design to examine how individual vulnerability for externalizing behavior… read more here.
Keywords: externalizing behaviors; dopamine receptor; household chaos;
Evaluating the conformational space of the active site of D2 dopamine receptor. Scope and limitations of the standard docking methods
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.26938
Abstract: We report here for the first time the potential energy surfaces (PES) of phenyletilamine (PEA) and meta‐tyramine (m‐OH‐PEA) at the D2 dopamine receptor (D2DR) binding site. PESs not only allow us to observe all the… read more here.
Keywords: standard docking; dopamine receptor; evaluating conformational; site ... See more keywords
Discovery research and development history of the dopamine D2 receptor partial agonists, aripiprazole and brexpiprazole
Sign Up to like & getrecommendations! Published in 2021 at "Neuropsychopharmacology Reports"
DOI: 10.1002/npr2.12180
Abstract: Otsuka Pharmaceutical Co., Ltd. successfully developed the first dopamine D2 receptor partial agonist approved for schizophrenia, the antipsychotic aripiprazole (Abilify®). The drug was approved for this indication in the United States in 2002 and has… read more here.
Keywords: receptor partial; disorder; dopamine receptor; partial agonists ... See more keywords
Comparative molecular field analysis and molecular dynamics studies of the dopamine D2 receptor antagonists without a protonatable nitrogen atom
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-018-2137-5
Abstract: AbstractThe dopaminergic hypothesis of schizophrenia is the main concept explaining the direct reasons of schizophrenia and the effectiveness of current antipsychotics. All antipsychotics present on the market are potent dopamine D2 receptor antagonists or partial… read more here.
Keywords: receptor; nitrogen atom; receptor antagonists; dopamine receptor ... See more keywords
Synthesis and dopamine receptor binding of dihydrexidine and SKF 38393 catecholamine-based analogues
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DOI: 10.1007/s00726-021-03106-4
Abstract: Dopamine is an important neurotransmitter that regulates numerous essential functions, including cognition and voluntary movement. As such, it serves as an important scaffold for synthesis of novel analogues as part of drug development effort to… read more here.
Keywords: synthesis; skf 38393; dopamine receptor;
Histamine Excites Striatal Dopamine D1 and D2 Receptor-Expressing Neurons via Postsynaptic H1 and H2 Receptors
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-0976-1
Abstract: The central histaminergic nervous system, originating from the tuberomammillary nucleus (TMN) of the hypothalamus, widely innervates almost the whole brain, including the basal ganglia. Intriguingly, the histaminergic system is altered in parkinsonian patients. Yet, little… read more here.
Keywords: histamine; dopamine receptor; receptor; basal ganglia ... See more keywords
α2A- and α2C-Adrenoceptors as Potential Targets for Dopamine and Dopamine Receptor Ligands
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1004-1
Abstract: The poor norepinephrine innervation and high density of Gi/o-coupled α2A- and α2C-adrenoceptors in the striatum and the dense striatal dopamine innervation have prompted the possibility that dopamine could be an effective adrenoceptor ligand. Nevertheless, the… read more here.
Keywords: adrenoceptors potential; potential targets; dopamine receptor; receptor ligands ... See more keywords