Lack of dopamine supersensitivity in rats after chronic administration of blonanserin: Comparison with haloperidol
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.04.014
Abstract: Abstract Long‐term treatment with antipsychotic drugs in patients with schizophrenia can lead to dopamine supersensitivity psychosis. It is reported that repeated administration of haloperidol caused dopamine supersensitivity in rats. Blonanserin is an atypical antipsychotic drug… read more here.
Keywords: chronic administration; blonanserin; dopamine supersensitivity; dopamine ... See more keywords
Neurotensin in the nucleus accumbens reverses dopamine supersensitivity evoked by antipsychotic treatment
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.05.015
Abstract: &NA; Long‐term exposure to antipsychotics like haloperidol can increase sensitivity to dopamine agonist stimulation. This could contribute to treatment failure and increase relapse to psychosis. Chronic antipsychotic treatment elevates neurotensin levels in the nucleus accumbens… read more here.
Keywords: dopamine supersensitivity; treatment; neurotensin; hal ... See more keywords
Long-Term Treatment With Long-Acting Injectable Antipsychotic in Schizophrenia Patients With and Without Dopamine Supersensitivity Psychosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Psychopharmacology"
DOI: 10.1097/jcp.0000000000001564
Abstract: Abstract Background Dopamine supersensitivity psychosis (DSP) is an unstable psychotic state in patients with schizophrenia due to an upregulation of dopamine D2 receptors induced by antipsychotic medication. Long-acting antipsychotic injectable (LAI) could be advantageous for… read more here.
Keywords: introduction; dopamine supersensitivity; long acting; supersensitivity psychosis ... See more keywords
Metabolism of risperidone by CYP2D6 and the presence of drug-induced dopamine supersensitivity psychosis in patients with schizophrenia
Sign Up to like & getrecommendations! Published in 2019 at "International Clinical Psychopharmacology"
DOI: 10.1097/yic.0000000000000257
Abstract: High-dose antipsychotic(s) can induce dopamine supersensitivity psychosis in schizophrenia patients. The precise relationship between a drug’s blood concentration and the occurrence of dopamine supersensitivity psychosis has not been established. We divided 36 patients with schizophrenia… read more here.
Keywords: cyp2d6; risperidone; supersensitivity psychosis; dopamine supersensitivity ... See more keywords
Treatment-resistant schizophrenia characterised by dopamine supersensitivity psychosis and efficacy of asenapine
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DOI: 10.1136/bcr-2021-242495
Abstract: Dopamine supersensitivity psychosis (DSP) frequently arises with long-term antipsychotic treatment and accounts for a significant proportion of treatment-resistant schizophrenia. The mechanism underlying DSP is thought to be a compensatory increase in dopamine receptor density in… read more here.
Keywords: treatment resistant; dopamine supersensitivity; supersensitivity psychosis; resistant schizophrenia ... See more keywords
Plasma monoamines change under dopamine supersensitivity psychosis in patients with schizophrenia: A comparison with first-episode psychosis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Psychopharmacology"
DOI: 10.1177/0269881119900982
Abstract: Background: Patients with first-episode psychosis respond well to initial antipsychotic treatment, but among patients experiencing a relapse of psychosis, the response rate falls to approximately 30%. The mechanism of this discrepancy has not been clarified,… read more here.
Keywords: dopamine supersensitivity; supersensitivity psychosis; first episode; episode psychosis ... See more keywords
Antipsychotic Induced Dopamine Supersensitivity Psychosis: A Comprehensive Review
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DOI: 10.2174/1570159x14666160606093602
Abstract: Chronic prescription of antipsychotics seems to lose its therapeutic benefits in the prevention of recurring psychotic symptoms. In many instances, the occurrence of relapse from initial remission is followed by an increase in dose of… read more here.
Keywords: supersensitivity psychosis; antipsychotic induced; dopamine supersensitivity; dopamine ... See more keywords