Dopamine synthesis in alcohol drinking-prone and -resistant mouse strains.
Sign Up to like & getrecommendations! Published in 2017 at "Alcohol"
DOI: 10.1016/j.alcohol.2016.05.005
Abstract: Alcoholism is a prevalent and debilitating neuropsychiatric disease, and much effort has been aimed at elucidating the neurobiological mechanisms underlying maladaptive alcohol drinking in an effort to design rational treatment strategies. In preclinical literature, the… read more here.
Keywords: mouse strains; alcohol; dopamine synthesis; dopamine ... See more keywords
The Effects of Antipsychotic Treatment on Presynaptic Dopamine Synthesis Capacity in First-Episode Psychosis: A Positron Emission Tomography Study
Sign Up to like & getrecommendations! Published in 2019 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2018.07.003
Abstract: Background Elevated striatal dopamine synthesis capacity has been implicated in the etiology and antipsychotic response in psychotic illness. The effects of antipsychotic medication on dopamine synthesis capacity are poorly understood, and no prospective studies have… read more here.
Keywords: synthesis capacity; treatment; dopamine synthesis;
Normative data of dopaminergic neurotransmission functions in substantia nigra measured with MRI and PET: Neuromelanin, dopamine synthesis, dopamine transporters, and dopamine D2 receptors
Sign Up to like & getrecommendations! Published in 2017 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2017.06.066
Abstract: The central dopaminergic system is of major importance in the pathophysiology of Parkinson's disease, schizophrenia, and other neuropsychiatric disorders. In the present study, the normative data of dopaminergic neurotransmission functions in the midbrain, consisting of… read more here.
Keywords: neuromelanin accumulation; dopamine; substantia nigra; dopamine transporters ... See more keywords
Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it: a translational imaging study with ketamine
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-0740-6
Abstract: Patients with schizophrenia show increased striatal dopamine synthesis capacity in imaging studies. The mechanism underlying this is unclear but may be due to N-methyl-D-aspartate receptor (NMDAR) hypofunction and parvalbumin (PV) neuronal dysfunction leading to disinhibition… read more here.
Keywords: sub chronic; synthesis capacity; ketamine; dopamine ... See more keywords
Elevated Dopamine Synthesis as a Mechanism of Cognitive Resilience in Aging.
Sign Up to like & getrecommendations! Published in 2021 at "Cerebral cortex"
DOI: 10.1093/cercor/bhab379
Abstract: Aging is associated with declines in multiple components of the dopamine system including loss of dopamine-producing neurons, atrophy of the dopamine system's cortical targets, and reductions in the density of dopamine receptors. Countering these patterns,… read more here.
Keywords: synthesis capacity; mechanism cognitive; elevated dopamine; dopamine synthesis ... See more keywords
The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]‐DOPA PET study
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy242
Abstract: Abstract Whilst the role of the Disrupted‐in‐Schizophrenia 1 (DISC1) gene in the aetiology of major mental illnesses is debated, the characterization of its function lends it credibility as a candidate. A key aspect of this… read more here.
Keywords: synthesis capacity; dopamine synthesis; disc1; synthesis ... See more keywords
S146. ASSOCIATION OF IMPAIRED MODEL-FREE DECISION-MAKING WITH ABERRANT STRIATAL DOPAMINE, BRAIN ACTIVATION, AND COGNITIVE DIFFICULTIES IN PATIENTS WITH SCHIZOPHRENIA DURING PSYCHOTIC REMISSION
Sign Up to like & getrecommendations! Published in 2020 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sbaa031.212
Abstract: Abstract Background Human decision-making ranges between the extremes of automatic and fast model-free behavior (i.e., relying only on previous outcomes) and more flexible, but computationally demanding model-based behavior (i.e., implementing cognitive models). Model-based/model-free decision-making can… read more here.
Keywords: decision; free decision; decision making; dopamine synthesis ... See more keywords
9.2 BRAIN STRUCTURAL AND NEUROCHEMICAL HETEROGENEITY AND HOMOGENEITY IN PSYCHOTIC DISORDERS: TRANSDIAGNOSTIC PET AND MRI IMAGING FINDINGS IN SCHIZOPHRENIA AND BIPOLAR AFFECTIVE DISORDER
Sign Up to like & getrecommendations! Published in 2018 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sby014.030
Abstract: Abstract Background Psychosis is seen in a number of disorders and treated with the same drugs. However, there is considerable variability in response to treatment and clinical course. Understanding the neurobiology underlying psychosis across diagnoses… read more here.
Keywords: schizophrenia; affective disorder; bipolar affective; psychotic disorders ... See more keywords
O3.5. TESTING THE DOPAMINE HYPOTHESIS OF PSYCHOSIS USING POSITRON EMISSION TOMOGRAPHIC IMAGING IN FIRST EPISODE BIPOLAR AFFECTIVE DISORDER AND SCHIZOPHRENIA
Sign Up to like & getrecommendations! Published in 2018 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sby015.203
Abstract: Abstract Background The dopamine hypothesis of psychosis suggests that dopamine abnormalities are present in psychotic illness, irrespective of diagnostic class. Meta-analyses of Positron Emission Tomography (PET) studies of the dopamine system have shown elevated dopamine… read more here.
Keywords: schizophrenia; synthesis capacity; positron emission; dopamine synthesis ... See more keywords
Evidence for absence of links between striatal dopamine synthesis capacity and working memory capacity, spontaneous eye-blink rate, and trait impulsivity
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.83161
Abstract: Individual differences in striatal dopamine synthesis capacity have been associated with working memory capacity, trait impulsivity and spontaneous eye-blink rate (sEBR), as measured with readily available and easily administered, ‘off-the-shelf’ tests. Such findings have raised… read more here.
Keywords: dopamine synthesis; synthesis capacity; working memory; striatal dopamine ... See more keywords