Copper Increases Brain Oxidative Stress and Enhances the Ability of 6-Hydroxydopamine to Cause Dopaminergic Degeneration in a Rat Model of Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1274-7
Abstract: Redox properties enable copper to perform its essential role in many biological processes, but they can also convert it into a potentially hazardous element. Its dyshomeostasis may have serious neurological consequences, and its possible involvement… read more here.
Keywords: increase; dopaminergic degeneration; copper; oxidative stress ... See more keywords
Age-related vulnerability to nigral dopaminergic degeneration in rats via Zn2+-permeable GluR2-lacking AMPA receptor activation.
Sign Up to like & getrecommendations! Published in 2021 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2020.12.014
Abstract: On the basis of the evidence that extracellular Zn2+ influx induced with AMPA causes Parkinson's syndrome in rats that apomorphine-induced movement disorder emerges, here we used a low dose of AMPA, which does not increase… read more here.
Keywords: aged rats; nigral dopaminergic; dopaminergic degeneration; intracellular zn2 ... See more keywords
Apathy Reflects Extra-Striatal Dopaminergic Degeneration in de novo Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Parkinson's disease"
DOI: 10.3233/jpd-223223
Abstract: BACKGROUND Apathy represents a core neuropsychiatric symptom in Parkinson's disease (PD). As there is currently no established effective treatment for apathy in PD, further investigating the biological origin of this symptom is needed to design… read more here.
Keywords: extra striatal; dopaminergic degeneration; parkinson disease; striatal dopaminergic ... See more keywords