Impaired autophagy in microglia aggravates dopaminergic neurodegeneration by regulating NLRP3 inflammasome activation in experimental models of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.10.010
Abstract: Microglia-mediated inflammation plays an important role in the pathogenesis of several neurodegenerative diseases including Parkinson's disease (PD). Recently, autophagy has been linked to the regulation of the inflammatory response. However, the potential role of microglial… read more here.
Keywords: microglial autophagy; neurodegeneration; dopaminergic neurodegeneration; autophagy ... See more keywords
α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2017.05.014
Abstract: Proteinaceous inclusions in neurons, composed primarily of α-synuclein, define the pathology in several neurodegenerative disorders. Neurons can internalize α-synuclein fibrils that can seed new inclusions from endogenously expressed α-synuclein. The factors contributing to the spread… read more here.
Keywords: inclusion spread; dopaminergic neurodegeneration; spread; pathology ... See more keywords
Lipopolysaccharide-induced functional and structural injury of the mitochondria in the nigrostriatal pathway
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Research"
DOI: 10.1016/j.neures.2016.09.007
Abstract: Accumulating evidence suggests that chronic inflammation plays a role in the progressive dopaminergic neurodegeneration that occurs in Parkinson's disease. It has been hypothesized that inflammation mediates neuronal damage via exacerbation of a vicious cycle of… read more here.
Keywords: functional structural; lipopolysaccharide induced; lps induced; dopaminergic neurodegeneration ... See more keywords
Lactoferrin ameliorates dopaminergic neurodegeneration and motor deficits in MPTP-treated mice
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2018.101090
Abstract: Brain iron accumulation is common in patients with Parkinson's disease (PD). Iron chelators have been investigated for their ability to prevent neurodegenerative diseases with features of iron overload. Given the non-trivial side effects of classical… read more here.
Keywords: mptp induced; lactoferrin ameliorates; ameliorates dopaminergic; dopaminergic neurodegeneration ... See more keywords
Sorbus alnifolia protects dopaminergic neurodegeneration in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2016.1251468
Abstract: Abstract Context: The twigs of Sorbus alnifolia (Sieb. et Zucc.) K. Koch (Rosaceae) have been used to treat neurological disorders as a traditional medicine in Korea. However, there are limited data describing the efficacy of… read more here.
Keywords: sorbus alnifolia; caenorhabditis elegans; neurodegeneration; dopaminergic neurodegeneration ... See more keywords
Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1101/2022.02.23.481573
Abstract: The fine-tuning of gene expression is critical for all cellular processes; aberrations in this activity can lead to pathology, and conversely, resilience. As their role in coordinating organismal responses to both internal and external factors… read more here.
Keywords: dopaminergic neurodegeneration; sid; rna interference; pathology ... See more keywords
MiR-132-3p promotes neuroinflammation and dopaminergic neurodegeneration by suppressing glutaredoxin expression.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neurochemistry"
DOI: 10.1111/jnc.15477
Abstract: This study aimed to investigate the effect of miR-132-3p/GLRX on neuroinflammation and dopaminergic neurodegeneration in Parkinson's disease (PD). In clinical experiments, the levels of miR-132-3p and glutaredoxin (GLRX) in the midbrain tissuesfrom 5 patients with… read more here.
Keywords: neuroinflammation dopaminergic; mir 132; dopaminergic neurodegeneration; expression ... See more keywords
The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-019-1659-1
Abstract: BackgroundMetabolic dysfunction and neuroinflammation are increasingly implicated in Parkinson’s disease (PD). The pentose phosphate pathway (PPP, a metabolic pathway parallel to glycolysis) converts glucose-6-phosphate into pentoses and generates ribose-5-phosphate and NADPH thereby governing anabolic biosynthesis… read more here.
Keywords: g6pd; neuroinflammation; neurodegeneration; dopaminergic neurodegeneration ... See more keywords
Substantia Nigra Hyperechogenicity Reflects the Progression of Dopaminergic Neurodegeneration in 6-OHDA Rat Model of Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2020.00216
Abstract: Parkinson’s disease (PD) is the second most common neurodegenerative disease, and there is still no effective way to stop its progress. Therefore, early detection is crucial for the prevention and the treatment of Parkinson’s disease.… read more here.
Keywords: disease; substantia nigra; dopaminergic neurodegeneration; progression dopaminergic ... See more keywords
Microglial Activation Damages Dopaminergic Neurons through MMP-2/-9-Mediated Increase of Blood-Brain Barrier Permeability in a Parkinson’s Disease Mouse Model
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052793
Abstract: Chronic neuroinflammation has been considered to be involved in the progressive dopaminergic neurodegeneration in Parkinson’s disease (PD). However, the mechanisms remain unknown. Accumulating evidence indicated a key role of the blood–brain barrier (BBB) dysfunction in… read more here.
Keywords: dopaminergic neurodegeneration; activation; microglial activation; rotenone ... See more keywords