UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202103396
Abstract: Netrin‐1 is a chemotropic cue mediating axon growth and neural migration in neuronal development, and its receptors deletion in colorectal cancer and UNC5s act as dependence receptors regulating neuronal apoptosis. Asparagine endopeptidase (AEP) is an… read more here.
Keywords: unc5c receptor; aep; dopaminergic neuronal; parkinson disease ... See more keywords
Dextromethorphan reduces prenatal lipopolysaccharide exposure‐induced dopaminergic neuronal loss and cytokine changes in offspring
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10180
Abstract: Maternal infection during pregnancy may affect fetal brain development and increase the risk of developing neurological and mental disorders later in life in offspring. In this study, we used low‐dose lipopolysaccharide (LPS) injection to mimic… read more here.
Keywords: dopaminergic neuronal; dextromethorphan; neuronal loss; maternal infection ... See more keywords
Autophagy Stimulation Decreases Dopaminergic Neuronal Death Mediated by Oxidative Stress
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-01654-1
Abstract: The neurodegenerative process of Parkinson’s disease (PD) involves autophagy impairment and oxidative stress. Therefore, we wanted to determine whether stimulation of autophagy protects dopaminergic cell death induced by oxidative stress in a PD model. Since… read more here.
Keywords: dopaminergic neuronal; death; autophagy stimulation; stress ... See more keywords
Human organotypic brain model as a tool to study chemical-induced dopaminergic neuronal toxicity
Sign Up to like & getrecommendations! Published in 2022 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2022.105719
Abstract: Oxidative stress is caused by an imbalance between the generation and detoxification of reactive oxygen and nitrogen species (ROS/RNS). This imbalance plays an important role in brain aging and age-related neurodegenerative diseases. In the context… read more here.
Keywords: study; dopaminergic neuronal; dopaminergic neurons; oxidative stress ... See more keywords
22(R)-hydroxycholesterol for dopaminergic neuronal specification of MSCs and amelioration of Parkinsonian symptoms in rats
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-020-00351-6
Abstract: Oxysterols play vital roles in the human body, ranging from cell cycle regulation and progression to dopaminergic neurogenesis. While naïve human mesenchymal stem cells (hMSCs) have been explored to have neurogenic effect, there is still… read more here.
Keywords: dopaminergic neuronal; effect; hydroxycholesterol dopaminergic; neuronal specification ... See more keywords
Transcranial magnetic stimulation promotes the proliferation of dopaminergic neuronal cells in vitro
Sign Up to like & getrecommendations! Published in 2018 at "AIP Advances"
DOI: 10.1063/1.5007677
Abstract: Transcranial magnetic stimulation (TMS) is a safe and non-invasive treatment for neurological disorders. TMS has been approved as a treatment for major depressive disorders by the US Food and Drug Administration (FDA) in 2008. Due… read more here.
Keywords: magnetic fields; dopaminergic neuronal; field; transcranial magnetic ... See more keywords
Unscrambling the Role of Redox-Active Biometals in Dopaminergic Neuronal Death and Promising Metal Chelation-Based Therapy for Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021256
Abstract: Biometals are all metal ions that are essential for all living organisms. About 40% of all enzymes with known structures require biometals to function correctly. The main target of damage by biometals is the central… read more here.
Keywords: dopaminergic neuronal; redox active; neuronal death; parkinson disease ... See more keywords
Tat‑aldose reductase prevents dopaminergic neuronal cell death by inhibiting oxidative stress and MAPK activation.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of molecular medicine"
DOI: 10.3892/ijmm.2020.4812
Abstract: Aldose reductase (AR) is known to detoxify aldehydes and prevent oxidative stress. Although AR exerts antioxidant effects, the role of AR in Parkinson's disease (PD) remains unclear. The objective of the present study was to… read more here.
Keywords: dopaminergic neuronal; death; aldose reductase; cell death ... See more keywords
Tp53 gene mediates distinct dopaminergic neuronal damage in different dopaminergic neurotoxicant models
Sign Up to like & getrecommendations! Published in 2017 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.215243
Abstract: Tp53, a stress response gene, is involved in diverse cell death pathways and its activation is implicated in the pathogenesis of Parkinson's disease. However, whether the neuronal Tp53 protein plays a direct role in regulating… read more here.
Keywords: dopaminergic neuronal; tp53 gene; damage different; damage ... See more keywords