microRNA‐221 rescues the loss of dopaminergic neurons in a mouse model of Parkinson's disease
Sign Up to like & getrecommendations! Published in 2023 at "Brain and Behavior"
DOI: 10.1002/brb3.2921
Abstract: Parkinson's disease (PD) is one of the most common systemic neurodegenerative diseases and is related to the loss of dopaminergic neurons in the substantia nigra. Several studies verified that microRNA (miRNAs) targeting the Bim/Bax/caspase‐3 signaling… read more here.
Keywords: loss dopaminergic; parkinson disease; dopaminergic neurons;
Preparation and Co‐Culture of iPSC‐Derived Dopaminergic Neurons and Astrocytes
Sign Up to like & getrecommendations! Published in 2019 at "Current Protocols in Cell Biology"
DOI: 10.1002/cpcb.98
Abstract: Induced pluripotent stem cell (iPSC)‐based models are powerful tools to study neurodegenerative diseases such as Parkinson's disease. The differentiation of patient‐derived neurons and astrocytes allows investigation of the molecular mechanisms responsible for disease onset and… read more here.
Keywords: dopaminergic neurons; preparation culture; ipsc; neurons astrocytes ... See more keywords
Neuroglial transmitophagy and Parkinson's disease
Sign Up to like & getrecommendations! Published in 2020 at "Glia"
DOI: 10.1002/glia.23839
Abstract: Mitophagy is essential for the health of dopaminergic neurons because mitochondrial damage is a keystone of Parkinson's disease. The aim of the present work was to study the degradation of mitochondria in the degenerating dopaminergic… read more here.
Keywords: transmitophagy; damaged mitochondria; disease; parkinson disease ... See more keywords
Idiopathic Parkinson's disease patient‐derived induced pluripotent stem cells function as midbrain dopaminergic neurons in rodent brains
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24014
Abstract: Patient‐specific induced pluripotent stem cells (iPSCs) are a promising source for cell transplantation therapy. In Parkinson's disease (PD) patients, however, their vulnerability and the transmission of pathological α‐Synuclein are possible drawbacks that may prevent PD‐specific… read more here.
Keywords: induced pluripotent; pluripotent stem; parkinson disease; dopaminergic neurons ... See more keywords
Towards better cellular replacement therapies in Parkinson disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24123
Abstract: Parkinson disease (PD) is a leading neurodegenerative disorder that affects more than 1% of the population aged 65 and above (de Rijk et al., 2000). With a growing aging population globally, more effective therapeutic regimes… read more here.
Keywords: transplantation; clinical trials; parkinson disease; dopaminergic neurons ... See more keywords
Reversing a Model of Parkinson's Disease With In Situ Converted Nigral Neurons
Sign Up to like & getrecommendations! Published in 2020 at "Movement Disorders"
DOI: 10.1002/mds.28306
Abstract: Contemporary management of Parkinson’s disease is directed at symptom control. To date, there are no disease-modifying therapies. Efforts at preventing or restoring neuronal loss and protecting degenerating circuits have been disappointing. Early efforts at cell… read more here.
Keywords: dopamine; disease; parkinson disease; dopaminergic neurons ... See more keywords
Disruption of Mitochondrial Complex I Induces Progressive Parkinsonism
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders"
DOI: 10.1002/mds.28961
Abstract: Mitochondrial dysfunction is recognized as being an important mechanism through which Parkinson’s disease (PD) can arise. In particular, decrease of mitochondrial complex 1 (MCI) activity in dopaminergic neurons of the substantia nigra (SN) has been… read more here.
Keywords: mitochondrial complex; mci; parkinsonism; dopaminergic neurons ... See more keywords
Extensive exploration of a novel rat model of Parkinson's disease using partial 6‐hydroxydopamine lesion of dopaminergic neurons suggests new therapeutic approaches
Sign Up to like & getrecommendations! Published in 2019 at "Synapse"
DOI: 10.1002/syn.22077
Abstract: Parkinson's disease (PD) is characterized by the degeneration of dopaminergic (DA) neurons constituting the nigrostriatal pathway. Neuroinflammation, related to microglial activation, plays an important role in this process. Exploration of animal models of PD using… read more here.
Keywords: exploration; disease; parkinson disease; dopaminergic neurons ... See more keywords
Generation of Induced Dopaminergic Neurons from Human Fetal Fibroblasts.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1601-7_7
Abstract: Since the first demonstration of direct dopaminergic neuronal reprogramming, over a dozen methods have been developed to generate induced dopaminergic neurons from various sources of cells. Here, we first present an overview of the different… read more here.
Keywords: generate induced; human fetal; generation induced; induced dopaminergic ... See more keywords
MEK/ERK Signaling Regulates Reconstitution of the Dopaminergic Nerve Circuit in the Planarian Dugesia japonica.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-020-03226-5
Abstract: Planarian Dugesia japonica is a flatworm that can autonomously regenerate its own body after an artificial amputation. A recent report showed the role of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK/ERK) pathway in the head… read more here.
Keywords: mek erk; dopaminergic neurons; planarian dugesia; regeneration ... See more keywords
Quinacrine and Niclosamide Promote Neurite Growth in Midbrain Dopaminergic Neurons Through the Canonical BMP-Smad Pathway and Protect Against Neurotoxin and α-Synuclein-Induced Neurodegeneration.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02351-8
Abstract: Parkinson's disease is a neurodegenerative disorder characterised by nigrostriatal dopaminergic degeneration, and intracellular α-synuclein aggregation. Current pharmacological treatments are solely symptomatic so there is a need to identify agents that can slow or stop dopaminergic… read more here.
Keywords: dopaminergic neurons; synuclein; quinacrine niclosamide; bmp smad ... See more keywords