Dopamine receptor D2, but not D1, mediates descending dopaminergic pathway–produced analgesic effect in a trigeminal neuropathic pain mouse model
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DOI: 10.1097/j.pain.0000000000001414
Abstract: Abstract Neuropathic pain represents a challenge to clinicians because it is resistant to commonly prescribed analgesics due to its largely unknown mechanisms. Here, we investigated a descending dopaminergic pathway–mediated modulation of trigeminal neuropathic pain. We… read more here.
Keywords: dopaminergic pathway; descending dopaminergic; neuropathic pain; spinal trigeminal ... See more keywords
Dopaminergic Pathway Genes Influence Adverse Events Related to Dopaminergic Treatment in Parkinson's Disease
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DOI: 10.3389/fphar.2019.00008
Abstract: Dopaminergic pathway is the most disrupted pathway in the pathogenesis of Parkinson's disease. Several studies reported associations of dopaminergic genes with the occurrence of adverse events of dopaminergic treatment. However, none of these studies adopted… read more here.
Keywords: dopaminergic pathway; adverse events; dopaminergic treatment; parkinson disease ... See more keywords
α-Synuclein Aggregates in the Nigro-Striatal Dopaminergic Pathway Impair Fine Movement: Partial Reversal by the Adenosine A2A Receptor Antagonist
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DOI: 10.3390/ijms24021365
Abstract: Parkinson’s disease (PD) is characterized pathologically by abnormal aggregation of alpha-synuclein (α-Syn) in the brain and clinically by fine movement deficits at the early stage, but the roles of α-Syn and associated neural circuits and… read more here.
Keywords: dopaminergic pathway; movement; fine movement; adenosine a2a ... See more keywords