Evaluation of the Pharmacokinetics of Metformin Following Coadministration With Doravirine in Healthy Volunteers
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.685
Abstract: Doravirine is a novel nonnucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus type‐1 (HIV‐1) infection. In vitro and clinical data suggest that doravirine is unlikely to cause significant drug–drug interactions via major… read more here.
Keywords: doravirine; coadministration doravirine; drug; following coadministration ... See more keywords
Evaluation of the Pharmacokinetic Interaction Between Doravirine and Methadone
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.699
Abstract: Doravirine is a novel nonnucleoside reverse transcriptase inhibitor indicated for the treatment of HIV type 1 infection. A subset of people living with HIV receives methadone for the treatment of opioid addiction. The current study… read more here.
Keywords: doravirine; plasma concentration; doravirine methadone; methadone ... See more keywords
Efficacy and safety of doravirine in treatment-naive HIV-1-infected adults: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-020-11267-0
Abstract: This research aims to study the safety and efficacy of doravirine in the treatment of HIV-1 (human immunodeficiency virus) patients. We conducted an electronic search in eight databases for the inclusion of eligible studies. We… read more here.
Keywords: doravirine; safety; efficacy; doravirine treatment ... See more keywords
A Randomized Trial to Assess the Effect of Doravirine on the QTc Interval Using a Single Supratherapeutic Dose in Healthy Adult Volunteers
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DOI: 10.1007/s40261-017-0552-x
Abstract: IntroductionDoravirine is a novel HIV-1 non-nucleoside reverse transcriptase inhibitor exhibiting a robust safety and efficacy profile in combination with other antiretrovirals. While existing data do not suggest that doravirine delays cardiac repolarization, the aim of… read more here.
Keywords: doravirine; qtc; trial; qtc interval ... See more keywords
Rational Design of Doravirine: From Bench to Patients.
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DOI: 10.1021/acsinfecdis.9b00178
Abstract: Since the approval of nevirapine, the first HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) in 1996, NNRTIs have helped play a critical role in maintaining viral suppression in people living with HIV. The many positive attributes… read more here.
Keywords: doravirine; doravirine bench; rational design; bench patients ... See more keywords
Efficacy and safety of Doravirine-based regimens in real life: a prospective, monocentric, French study.
Sign Up to like & getrecommendations! Published in 2022 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2022.0058
Abstract: Doravirine (DOR) efficacy and safety has been evaluated in adult naïve or treated patients starting a DOR-based regimen between 09/15/2019 and 12/31/2020. Medical history and examination, laboratory results, tolerance were assessed during the 48 weeks… read more here.
Keywords: efficacy safety; dor; based regimens; doravirine ... See more keywords
Investigation of Pharmacokinetic Interactions between Doravirine and Elbasvir-Grazoprevir and Ledipasvir-Sofosbuvir
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DOI: 10.1128/aac.02491-18
Abstract: Doravirine is a non-nucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. Due to the high prevalence of HIV-1 and hepatitis C virus (HCV) coinfection and coadministration of HIV-1… read more here.
Keywords: ledipasvir sofosbuvir; doravirine; elbasvir grazoprevir; grazoprevir ledipasvir ... See more keywords
3 The exposure to and efficacy of doravirine in pregnant women as assessed by physiologically-based pharmacokinetic modelling
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DOI: 10.1136/archdischild-2023-esdppp.3
Abstract: Introduction Doravirine is currently not recommended for pregnant women living with HIV due to the lack of efficacy and safety data. Physiological changes during pregnancy can significantly decrease drug exposure, and, thereby, lower the efficacy.… read more here.
Keywords: doravirine; efficacy; pregnant women; model ... See more keywords
High Prevalence of Doravirine Resistance in HIV-1-Infected Patients with Virological Failure to an NNRTI-Based Single-Tablet Regimen
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DOI: 10.2147/idr.s361012
Abstract: Purpose This study aimed to investigate the prevalence of resistance to a non-nucleoside reverse transcriptase inhibitor (NNRTI)-based single-tablet regimen (STR) in Taiwanese patients and clarify the clinical implications of using doravirine in patients who fail… read more here.
Keywords: prevalence; nnrti based; doravirine; resistance ... See more keywords
Determination of Doravirine in human plasma using liquid-liquid extraction and HPLC-MS/MS.
Sign Up to like & getrecommendations! Published in 2019 at "Bioanalysis"
DOI: 10.4155/bio-2019-0116
Abstract: Aim: A method to quantitate Doravirine (MK-1439) in human plasma has been developed to support human clinical trials designed to evaluate the safety, pharmacokinetics and efficacy of the compound. Methodology & results: The analyte was… read more here.
Keywords: doravirine; human plasma; liquid extraction; liquid liquid ... See more keywords