Highly Synergistic Effects of Melittin with Conventional Antibiotics Against Multidrug-Resistant Isolates of Acinetobacter baumannii and Pseudomonas aeruginosa.
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DOI: 10.1089/mdr.2018.0016
Abstract: BACKGROUND Morbidity and mortality due to multidrug-resistant (MDR) bacteria are of great concern in burn patients. In this critical condition, synergism between antimicrobial peptides and conventional antibiotics would be a promising strategy. Accordingly, this study… read more here.
Keywords: isolates acinetobacter; melittin; conventional antibiotics; multidrug resistant ... See more keywords
Pharmacokinetics and Safety of Doripenem in Healthy Chinese Subjects and Monte Carlo Dosing Simulations
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DOI: 10.3390/antibiotics11070958
Abstract: The aim of this study was to investigate the pharmacokinetics (PK) of doripenem in healthy Chinese subjects and evaluate the optimal dosage regimens of doripenem. A randomized, single-dose, three-period, self-crossover controlled extended-infusion clinical trial was… read more here.
Keywords: chinese subjects; monte carlo; doripenem healthy; doripenem ... See more keywords
Fingolimod Promotes Antibacterial Effect of Doripenem against Carbapenem-Resistant Escherichia coli
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DOI: 10.3390/antibiotics11081043
Abstract: The aim of this study was to determine whether fingolimod could synergize the antibacterial activity of doripenem against carbapenem-resistant Escherichia coli (CREC) and its potential as an antibiotic adjuvant for doripenem. The E. coli used… read more here.
Keywords: carbapenem resistant; doripenem carbapenem; escherichia coli; fingolimod ... See more keywords
Carbapenem Combinations for Infections Caused by Carbapenemase-Producing Pseudomonas aeruginosa: Experimental In Vitro and In Vivo Analysis
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DOI: 10.3390/antibiotics11091212
Abstract: In the context of difficult-to-treat carbapenem-resistant Pseudomonas aeruginosa infections, we evaluated imipenem, meropenem, and doripenem combinations against eleven carbapenemase-producing P. aeruginosa isolates. According to the widespread global distribution of high-risk clones and carbapenemases, four representative… read more here.
Keywords: plus meropenem; carbapenem combinations; pseudomonas aeruginosa; doripenem ... See more keywords
Structural Analysis of The OXA-48 Carbapenemase Bound to A “Poor” Carbapenem Substrate, Doripenem
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DOI: 10.3390/antibiotics8030145
Abstract: Carbapenem-resistant Enterobacteriaceae are a significant threat to public health, and a major resistance determinant that promotes this phenotype is the production of the OXA-48 carbapenemase. The activity of OXA-48 towards carbapenems is a puzzling phenotype… read more here.
Keywords: structural analysis; doripenem; oxa carbapenemase; carbapenem ... See more keywords