Sex‐specific characteristics of cells expressing the cannabinoid 1 receptor in the dorsal horn of the lumbar spinal cord
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25342
Abstract: It is becoming increasingly clear that robust sex differences exist in the processing of acute and chronic pain in both rodents and humans. However, the underlying mechanism has not been well characterized. The dorsal horn… read more here.
Keywords: cord; lumbar; sex; spinal cord ... See more keywords
Complement 3a receptor in dorsal horn microglia mediates pronociceptive neuropeptide signaling
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23208
Abstract: The complement 3a receptor (C3aR1) participates in microglial signaling under pathological conditions and was recently shown to be activated by the neuropeptide TLQP‐21. We previously demonstrated that TLQP‐21 elicits hyperalgesia and contributes to nerve injury‐induced… read more here.
Keywords: tlqp; dorsal horn; complement receptor; horn microglia ... See more keywords
Anatomical changes in descending serotonergic projections from the rostral ventromedial medulla to the spinal dorsal horn following repetitive neonatal painful procedures
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10185
Abstract: Excessive noxious stimulation during the critical neonatal period impacts the nociceptive network lasting into adulthood. As descending serotonergic projections from the rostral ventromedial medulla (RVM) to the spinal dorsal horn develop postnatally, this study aims… read more here.
Keywords: repetitive neonatal; descending serotonergic; spinal dorsal; dorsal horn ... See more keywords
Spinal and Medullary Dorsal Horn Mechanisms
Sign Up to like & getrecommendations! Published in 2019 at "Pain"
DOI: 10.1007/978-3-319-99124-5_5
Abstract: The dorsal horn of the spinal cord is the first relay in the transmission of painful stimuli from the periphery to higher brain centers. Primary nociceptor terminals enter the dorsal horn and form synapses with… read more here.
Keywords: dorsal horn; medullary dorsal; spinal medullary; dorsal ... See more keywords
PKCγ interneurons, a gateway to pathological pain in the dorsal horn
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-020-02162-6
Abstract: Chronic pain is a frequent and disabling condition that is significantly maintained by central sensitization, which results in pathological amplification of responses to noxious and innocuous stimuli. As such, mechanical allodynia, or pain in response… read more here.
Keywords: dorsal horn; horn pkc; chronic pain; pain ... See more keywords
Neuroinflammation in Primary Cultures of the Rat Spinal Dorsal Horn Is Attenuated in the Presence of Adipose Tissue-Derived Medicinal Signalling Cells (AdMSCs) in a Co-cultivation Model.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02601-9
Abstract: Neuroinflammation within the superficial dorsal horn (SDH) of the spinal cord induces inflammatory pain with symptoms of hyperalgesia and allodynia. Glial activation and production of inflammatory mediators (e.g. cytokines) is associated with modulation of nociceptive… read more here.
Keywords: dorsal horn; medicinal signalling; signalling cells; cultivation ... See more keywords
Inhibition of interleukin-6 function attenuates the central sensitization and pain behavior induced by osteoarthritis.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2017.06.032
Abstract: Chronic pain is the most prominent and disabling symptom in the patients with osteoarthritis (OA), and the underlying mechanism largely remains unclear. Interleukin-6 (IL-6), a proinflammatory cytokine, is critically involved in the development and maintenance… read more here.
Keywords: dorsal horn; central sensitization; chronic pain; pain ... See more keywords
Inhibition of protein tyrosine phosphatase 1B in spinal cord dorsal horn of rats attenuated diabetic neuropathic pain
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.03.012
Abstract: Abstract Protein tyrosine phosphatase 1B (PTP1B) has been shown to dephosphorylate and inactivate insulin receptors, which contributes to the pathogenesis of diabetes. Neuropathic pain is one of the severe complications that results from diabetic neuropathy.… read more here.
Keywords: cord dorsal; dorsal horn; diabetic neuropathic; neuropathic pain ... See more keywords
Quercetin attenuates diabetic neuropathic pain by inhibiting mTOR/p70S6K pathway-mediated changes of synaptic morphology and synaptic protein levels in spinal dorsal horn of db/db mice.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173266
Abstract: Numerous studies indicate that the changes of synaptic morphology and synaptic protein levels in spinal dorsal horn neurons contributes to the development and maintenance of neuropathic pain. Quercetin, a bioflavonoid compound, has been shown to… read more here.
Keywords: spinal dorsal; dorsal horn; neuropathic pain; quercetin ... See more keywords
Effects of naftopidil on inhibitory transmission in substantia gelatinosa neurons of the rat spinal dorsal horn in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2017.07.030
Abstract: OBJECTIVE Naftopidil is used clinically for the treatment of voiding disorders in benign prostatic hyperplasia. Previous in vivo experiments in which naftopidil was applied intrathecally abolished rhythmic bladder contraction, suggesting that naftopidil might inhibit a… read more here.
Keywords: dorsal horn; substantia gelatinosa; spinal dorsal; dorsal ... See more keywords
Role of reactive astrocytes in the spinal dorsal horn under chronic itch conditions.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2020.07.010
Abstract: Astrocytes are the most abundant glial cells in the central nervous system (CNS), including the spinal cord. Neuronal damage induces astrocytes to become reactive and contribute to various CNS pathologies. Recent studies have demonstrated that… read more here.
Keywords: itch; spinal dorsal; dorsal horn; itch conditions ... See more keywords