Anatomical and neurochemical organization of the serotonergic system in the mammalian brain and in particular the involvement of the dorsal raphe nucleus in relation to neurological diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Progress in brain research"
DOI: 10.1016/bs.pbr.2021.02.003
Abstract: The brainstem is a neglected brain area in neurodegenerative diseases, including Alzheimer's and Parkinson's disease, frontotemporal lobar degeneration and autonomic dysfunction. In Depression, several observations have been made in relation to changes in one particular… read more here.
Keywords: raphe nucleus; area; relation; dorsal raphe ... See more keywords
The effects of local microinjection of selective dopamine D1 and D2 receptor agonists and antagonists into the dorsal raphe nucleus on sleep and wakefulness in the rat
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.11.006
Abstract: HIGHLIGHTSMicroinjection of SKF38393, bromocriptine and quinpirole into the DRN reduced REMS.Bromocriptine and quinpirole increased, in addition, wakefulness.The DAergic system plays a role in the regulation of the 5‐HT system. ABSTRACT The effects of the dopamine… read more here.
Keywords: raphe nucleus; dorsal raphe; receptor agonists; dopamine receptor ... See more keywords
Estrogen Withdrawal Increases Postpartum Anxiety via Oxytocin Plasticity in the Paraventricular Hypothalamus and Dorsal Raphe Nucleus
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DOI: 10.1016/j.biopsych.2020.11.016
Abstract: BACKGROUND Estrogen increases dramatically during pregnancy but quickly drops below prepregnancy levels at birth and remains suppressed during the postpartum period. Clinical and rodent work suggests that this postpartum drop in estrogen results in an… read more here.
Keywords: raphe nucleus; anxiety; estrogen withdrawal; estrogen ... See more keywords
Anxiolytic and panicolytic-like effects of environmental enrichment seem to be modulated by serotonin neurons located in the dorsal subnucleus of the dorsal raphe
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2019.06.012
Abstract: In a previous study, we showed that exposure of rats to a one-week environmental enrichment (EE) protocol decreases elevated T-maze (ETM) avoidance responses, an anxiolytic-like effect, without altering escape reactions, in clinical terms related to… read more here.
Keywords: anxiolytic panicolytic; panicolytic like; like effects; dorsal ... See more keywords
Dorsal Raphe Dual Serotonin-Glutamate Neurons Drive Reward by Establishing Excitatory Synapses on VTA Mesoaccumbens Dopamine Neurons
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DOI: 10.1016/j.celrep.2019.01.014
Abstract: SUMMARY Dorsal raphe (DR) serotonin neurons provide a major input to the ventral tegmental area (VTA). Here, we show that DR serotonin transporter (SERT) neurons establish both asymmetric and symmetric synapses on VTA dopamine neurons,… read more here.
Keywords: synapses vta; serotonin; mesoaccumbens dopamine; dorsal raphe ... See more keywords
Serotonin2B receptors in the rat dorsal raphe nucleus exert a GABA-mediated tonic inhibitory control on serotonin neurons
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2018.09.015
Abstract: &NA; The central serotonin2B receptor (5‐HT2BR) is a well‐established modulator of dopamine (DA) neuron activity in the rodent brain. Recent studies in rats have shown that the effect of 5‐HT2BR antagonists on accumbal and medial… read more here.
Keywords: raphe nucleus; drn; control; tonic inhibitory ... See more keywords
The modulation of the spatial reference memory by the orexinergic system of the dorsal raphe nucleus.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118777
Abstract: The dorsal raphe nucleus (DRN) is a brainstem nucleus involved in the pathophysiology of the depression, through its serotoninergic innervation. Furthermore, depressive symptoms in patients are also associated with some memory and sleep complaints. Anatomical… read more here.
Keywords: orexin; raphe nucleus; spatial reference; reference memory ... See more keywords
Serotonin2B receptor blockade in the rat dorsal raphe nucleus suppresses cocaine-induced hyperlocomotion through an opposite control of mesocortical and mesoaccumbens dopamine pathways
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.108309
Abstract: Serotonin2B receptor (5-HT2BR) antagonists inhibit cocaine-induced hyperlocomotion independently of changes of accumbal dopamine (DA) release. Given the tight relationship between accumbal DA activity and locomotion, and the inhibitory role of medial prefrontal cortex (mPFC) DA… read more here.
Keywords: induced hyperlocomotion; cocaine induced; serotonin2b receptor; dorsal raphe ... See more keywords
MicroRNA-34a regulates 5-HT2C expression in dorsal raphe and contributes to the anti-depressant-like effect of fluoxetine
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DOI: 10.1016/j.neuropharm.2021.108559
Abstract: Selective serotonin reuptake inhibitors (SSRIs) are designed to improve mood by raising extracellular serotonin levels through the blockade of the serotonin transporter. However, they exhibit a slow onset of action, suggesting the involvement of adaptive… read more here.
Keywords: ht2c; expression; dorsal; microrna 34a ... See more keywords
Glutamatergic Signals in the Dorsal Raphe Nucleus Regulate Maternal Aggression and Care in an Opposing Manner in Mice
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DOI: 10.1016/j.neuroscience.2018.12.034
Abstract: Lactating female mice nurture their pups and attack intruders in their territory. When an intruder invades a dam's territory, she needs to switch her behavior from care to aggression to protect her pups and territory.… read more here.
Keywords: glutamatergic signals; raphe nucleus; nurturing behavior; aggression ... See more keywords
Post-ictal Generalized EEG Suppression is reduced by Enhancing Dorsal Raphe Serotonergic Neurotransmission
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DOI: 10.1016/j.neuroscience.2020.11.029
Abstract: Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. A proposed risk marker for SUDEP is the duration of post-ictal generalized EEG suppression (PGES). The mechanisms underlying… read more here.
Keywords: generalized eeg; suppression; post ictal; eeg suppression ... See more keywords