The distribution of Cdh20 mRNA demarcates somatotopic subregions and subpopulations of spiny projection neurons in the rat dorsolateral striatum
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25215
Abstract: The dorsolateral striatum (DLS) of rodents is functionally subdivided into somatotopic subregions that represent each body part along both the dorsoventral and anteroposterior (A‐P) axes and play crucial roles in sensorimotor functions via corticostriatal pathways.… read more here.
Keywords: dls; projection neurons; dorsolateral striatum; spiny projection ... See more keywords
Habits Are Negatively Regulated by Histone Deacetylase 3 in the Dorsal Striatum
Sign Up to like & getrecommendations! Published in 2018 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2018.01.025
Abstract: BACKGROUND Optimal behavior and decision making result from a balance of control between two strategies, one cognitive/goal-directed and one habitual. These systems are known to rely on the anatomically distinct dorsomedial and dorsolateral striatum, respectively.… read more here.
Keywords: dorsal striatum; striatum; dorsolateral striatum; hdac3 ... See more keywords
P.2.021 Functional changes in the dorsolateral striatum in loss of control over reward seeking
Sign Up to like & getrecommendations! Published in 2018 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.12.060
Abstract: Substance addiction inflicts an enormous burden on patients with formidable costs to society. Loss of control over substance use is a hallmark of addiction. It marks the stage where substance use has progressed from casual… read more here.
Keywords: control reward; dls; dorsolateral striatum; loss control ... See more keywords
Eltoprazine prevents levodopa-induced dyskinesias by reducing causal interactions for theta oscillations in the dorsolateral striatum and substantia nigra pars reticulate
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.12.027
Abstract: ABSTRACT Oscillatory activities within basal ganglia (BG) circuitry in L‐DOPA induced dyskinesia (LID), a condition that occurs in patients with Parkinson disease (PD), are not well understood. The aims of this study were firstly to… read more here.
Keywords: lid rats; information; dorsolateral striatum; dstr snr ... See more keywords
Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25460-3
Abstract: Comparatively little is known about how new instrumental actions are encoded in the brain. Using whole-brain c-Fos mapping, we show that neural activity is increased in the anterior dorsolateral striatum (aDLS) of mice that successfully… read more here.
Keywords: adls disrupts; new instrumental; dorsolateral striatum; instrumental actions ... See more keywords
A Deficiency of the Psychiatric Risk Gene DLG2/PSD-93 Causes Excitatory Synaptic Deficits in the Dorsolateral Striatum
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.938590
Abstract: Genetic variations resulting in the loss of function of the discs large homologs (DLG2)/postsynaptic density protein-93 (PSD-93) gene have been implicated in the increased risk for schizophrenia, intellectual disability, and autism spectrum disorders (ASDs). Previously,… read more here.
Keywords: dorsolateral striatum; dlg2 psd; risk; gene ... See more keywords
Neural mechanism underlies CYLD modulation of morphology and synaptic function of medium spiny neurons in dorsolateral striatum
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1107355
Abstract: Although the deubiquitinase cylindromatosis (CYLD), an abundant protein in the postsynaptic density fraction, plays a crucial role in mediating the synaptic activity of the striatum, the precise molecular mechanism remains largely unclear. Here, using a… read more here.
Keywords: dorsolateral striatum; cyld; spiny neurons; activity ... See more keywords
Distinct recruitment of dorsomedial and dorsolateral striatum erodes with extended training
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.49536
Abstract: Hypotheses of striatal orchestration of behavior ascribe distinct functions to striatal subregions, with the dorsolateral striatum (DLS) especially implicated in habitual and skilled performance. Thus neural activity patterns recorded from the DLS, but not the… read more here.
Keywords: dorsolateral striatum; performance; training; extended training ... See more keywords