Satellite Repeats Identify X Chromatin for Dosage Compensation in Drosophila melanogaster Males
Sign Up to like & getrecommendations! Published in 2017 at "Current Biology"
DOI: 10.1016/j.cub.2017.03.078
Abstract: A common feature of sex chromosomes is coordinated regulation of X-linked genes in one sex. Drosophila melanogaster males have one X chromosome, whereas females have two. The resulting imbalance in gene dosage is corrected by… read more here.
Keywords: dosage compensation; satellite repeats; compensation; drosophila melanogaster ... See more keywords
Non-Canonical and Sexually Dimorphic X Dosage Compensation States in the Mouse and Human Germline
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DOI: 10.1016/j.devcel.2016.12.023
Abstract: Summary Somatic X dosage compensation requires two mechanisms: X inactivation balances X gene output between males (XY) and females (XX), while X upregulation, hypothesized by Ohno and documented in vivo, balances X gene with autosomal… read more here.
Keywords: dosage compensation; mouse human; non canonical; dosage ... See more keywords
X Chromosome Domain Architecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.08.004
Abstract: Mechanisms establishing higher-order chromosome structures and their roles in gene regulation are elusive. We analyzed chromosome architecture during nematode X chromosome dosage compensation, which represses transcription via a dosage-compensation condensin complex (DCC) that binds hermaphrodite… read more here.
Keywords: dosage compensation; chromosome; domain architecture;
Global chromatin conformation differences in the Drosophila dosage compensated chromosome X
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13350-8
Abstract: In Drosophila melanogaster the single male chromosome X undergoes an average twofold transcriptional upregulation for balancing the transcriptional output between sexes. Previous literature hypothesised that a global change in chromosome structure may accompany this process.… read more here.
Keywords: drosophila dosage; male chromosome; dosage compensation; chromosome ... See more keywords
Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation
Sign Up to like & getrecommendations! Published in 2020 at "Nature cell biology"
DOI: 10.1038/s41556-020-00607-4
Abstract: X-chromosome dosage compensation in female placental mammals is achieved by X-chromosome inactivation (XCI). An exception are human pre-implantation embryos, where dosage compensation occurs by X-chromosome dampening (XCD). Here, we examined whether XCD extends to human… read more here.
Keywords: dosage compensation; germ cells; dosage; chromosome dosage ... See more keywords
109 Dosage Compensation of the X Chromosome in Ovine Embryos, Late Gestation, and Adult Somatic Tissues
Sign Up to like & getrecommendations! Published in 2018 at "Reproduction, Fertility and Development"
DOI: 10.1071/rdv30n1ab109
Abstract: Deviations from proper gene dosage of the autosome range from severe to lethal consequences in mammals. Eutherian males (XY), however, have reduced gene dosage compared with females (XX) due to a single X and deteriorating… read more here.
Keywords: dosage compensation; rxe; expression; dosage ... See more keywords
The Evolution of Sex Chromosomes and Dosage Compensation in Plants
Sign Up to like & getrecommendations! Published in 2017 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evw282
Abstract: Plant sex chromosomes can be vastly different from those of the few historical animal model organisms from which most of our understanding of sex chromosome evolution is derived. Recently, we have seen several advancements from… read more here.
Keywords: dosage compensation; sex chromosome; evolution; plant ... See more keywords
Evolution of Sex Chromosome Dosage Compensation in Animals: A Beautiful Theory, Undermined by Facts and Bedeviled by Details
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DOI: 10.1093/gbe/evx154
Abstract: Abstract Many animals with genetic sex determination harbor heteromorphic sex chromosomes, where the heterogametic sex has half the gene dose of the homogametic sex. This imbalance, if reflected in the abundance of transcripts or proteins,… read more here.
Keywords: dosage compensation; sex; sex chromosome; theory ... See more keywords
Gene-by-Gene or Localized Dosage Compensation on the Neo-X Chromosome in Drosophila miranda
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DOI: 10.1093/gbe/evy148
Abstract: Abstract Many organisms have a global mechanism for dosage compensation (DC) operating along the entire male X chromosome, which equalizes gene expression on the male X with that on the two Xs in females and/or… read more here.
Keywords: dosage compensation; neo linked; gene gene; linked genes ... See more keywords
Dosage Compensation throughout the Schistosoma mansoni Lifecycle: Specific Chromatin Landscape of the Z Chromosome
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DOI: 10.1093/gbe/evz133
Abstract: Abstract Differentiated sex chromosomes are accompanied by a difference in gene dose between X/Z-specific and autosomal genes. At the transcriptomic level, these sex-linked genes can lead to expression imbalance, or gene dosage can be compensated… read more here.
Keywords: dosage compensation; chromatin; dosage; schistosoma mansoni ... See more keywords
Structural basis for interaction between CLAMP and MSL2 proteins involved in the specific recruitment of the dosage compensation complex in Drosophila
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac455
Abstract: Transcriptional regulators select their targets from a large pool of similar genomic sites. The binding of the Drosophila dosage compensation complex (DCC) exclusively to the male X chromosome provides insight into binding site selectivity rules.… read more here.
Keywords: interaction; clamp; specific recruitment; c2h2 ... See more keywords