Clinical utility of a model‐based amoxicillin dosage regimen in neonates with early‐onset sepsis
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DOI: 10.1111/bcp.15521
Abstract: Early‐onset sepsis (EOS) is one of the most significant causes of morbidity and mortality in neonates. Currently, amoxicillin is empirically used to treat neonates with EOS. However, data on its effectiveness in neonates with EOS… read more here.
Keywords: early onset; based amoxicillin; model; dosage regimen ... See more keywords
Rational determination of cefazolin dosage regimen in horses based on pharmacokinetics/pharmacodynamics principles and Monte Carlo simulations.
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DOI: 10.1111/jvp.13099
Abstract: A pharmacokinetics/pharmacodynamics (PK/PD) approach was used to determine the best empirical dosage regimen of cefazolin (CEZ) after intramuscular (IM) administration of CEZ in horses. Seven horses received a single IM or intravenous (IV) administration of… read more here.
Keywords: administration; monte carlo; pharmacokinetics pharmacodynamics; dosage ... See more keywords
Combating Carbapenem-Resistant Acinetobacter baumannii by an Optimized Imipenem-plus-Tobramycin Dosage Regimen: Prospective Validation via Hollow-Fiber Infection and Mathematical Modeling
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DOI: 10.1128/aac.02053-17
Abstract: ABSTRACT We aimed to prospectively validate an optimized combination dosage regimen against a clinical carbapenem-resistant Acinetobacter baumannii (CRAB) isolate (imipenem MIC, 32 mg/liter; tobramycin MIC, 2 mg/liter). Imipenem at constant concentrations (7.6, 13.4, and 23.3… read more here.
Keywords: resistant acinetobacter; fiber infection; dosage regimen; carbapenem resistant ... See more keywords
Plasma pharmacokinetics and dosage regimen of cefpirome sulfate in ewes
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DOI: 10.24099/vet.arhiv.1301
Abstract: Cefpirome is fourth- generation cephalosporin class of drug with a broad spectrum of activity against Grampositive and Gram- negative organisms. A pharmacokinetic study of single dose intravenous (IV) and intramuscular (IM) administration of cefpirome sulfate… read more here.
Keywords: administration cefpirome; administration; cefpirome sulfate; plasma ... See more keywords
Population Pharmacokinetic Modeling of Zaltoprofen in Healthy Adults: Exploring the Dosage Regimen
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DOI: 10.3390/ph16020161
Abstract: Zaltoprofen is a drug used for various pain and inflammatory diseases. Scientific and quantitative dosage regimen studies regarding its clinical application are scarce. This study aimed to discover effective covariates related to interindividual pharmacokinetic variability… read more here.
Keywords: dosage regimen; population pharmacokinetic; pharmacokinetic modeling; zaltoprofen ... See more keywords