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   Articles with "dosage regimen" as a keyword



Clinical utility of a model‐based amoxicillin dosage regimen in neonates with early‐onset sepsis

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recommendations! Published in 2022 at "British Journal of Clinical Pharmacology"

DOI: 10.1111/bcp.15521

Abstract: Early‐onset sepsis (EOS) is one of the most significant causes of morbidity and mortality in neonates. Currently, amoxicillin is empirically used to treat neonates with EOS. However, data on its effectiveness in neonates with EOS… read more here.

Keywords: early onset; based amoxicillin; model; dosage regimen ... See more keywords

Dosage Regimen Optimization of Ertapenem Against ESBL‐Producing Enterobacterales Infection in Critically Ill Patients Using Monte Carlo Simulation

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recommendations! Published in 2025 at "Clinical and Translational Science"

DOI: 10.1111/cts.70274

Abstract: ABSTRACT Extended‐spectrum beta‐lactamase (ESBL)‐producing Enterobacterales infections are associated with high mortality rates. Ertapenem is recommended as one of the first‐line drugs due to its efficacy against these pathogens. However, physiological changes in critically ill patients… read more here.

Keywords: producing enterobacterales; ill patients; esbl producing; dosage regimen ... See more keywords

Rational determination of cefazolin dosage regimen in horses based on pharmacokinetics/pharmacodynamics principles and Monte Carlo simulations.

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recommendations! Published in 2022 at "Journal of veterinary pharmacology and therapeutics"

DOI: 10.1111/jvp.13099

Abstract: A pharmacokinetics/pharmacodynamics (PK/PD) approach was used to determine the best empirical dosage regimen of cefazolin (CEZ) after intramuscular (IM) administration of CEZ in horses. Seven horses received a single IM or intravenous (IV) administration of… read more here.

Keywords: administration; monte carlo; pharmacokinetics pharmacodynamics; dosage ... See more keywords

Combating Carbapenem-Resistant Acinetobacter baumannii by an Optimized Imipenem-plus-Tobramycin Dosage Regimen: Prospective Validation via Hollow-Fiber Infection and Mathematical Modeling

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recommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.02053-17

Abstract: ABSTRACT We aimed to prospectively validate an optimized combination dosage regimen against a clinical carbapenem-resistant Acinetobacter baumannii (CRAB) isolate (imipenem MIC, 32 mg/liter; tobramycin MIC, 2 mg/liter). Imipenem at constant concentrations (7.6, 13.4, and 23.3… read more here.

Keywords: resistant acinetobacter; fiber infection; dosage regimen; carbapenem resistant ... See more keywords

Plasma pharmacokinetics and dosage regimen of cefpirome sulfate in ewes

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recommendations! Published in 2022 at "Veterinarski arhiv"

DOI: 10.24099/vet.arhiv.1301

Abstract: Cefpirome is fourth- generation cephalosporin class of drug with a broad spectrum of activity against Grampositive and Gram- negative organisms. A pharmacokinetic study of single dose intravenous (IV) and intramuscular (IM) administration of cefpirome sulfate… read more here.

Keywords: administration cefpirome; administration; cefpirome sulfate; plasma ... See more keywords

Rational quinidine dosage regimen for atrial fibrillation in Thoroughbred racehorses based on population pharmacokinetics

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recommendations! Published in 2024 at "Frontiers in Veterinary Science"

DOI: 10.3389/fvets.2024.1454342

Abstract: Introduction Quinidine (QND) sulfate is an effective treatment for atrial fibrillation (AF) in horses, and several dosage regimens have been proposed to address its wide variability in response and potential adverse effects. The purpose of… read more here.

Keywords: dosage; quinidine; dosage regimen; quinidine concentrations ... See more keywords

Population Pharmacokinetic Modeling of Zaltoprofen in Healthy Adults: Exploring the Dosage Regimen

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recommendations! Published in 2023 at "Pharmaceuticals"

DOI: 10.3390/ph16020161

Abstract: Zaltoprofen is a drug used for various pain and inflammatory diseases. Scientific and quantitative dosage regimen studies regarding its clinical application are scarce. This study aimed to discover effective covariates related to interindividual pharmacokinetic variability… read more here.

Keywords: dosage regimen; population pharmacokinetic; pharmacokinetic modeling; zaltoprofen ... See more keywords

Cost-effectiveness analysis of several dosage regimens of vancomycin in ventilator-associated pneumonia critically ill patients

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recommendations! Published in 2024 at "Journal of Applied Pharmaceutical Science"

DOI: 10.7324/japs.2024.194102

Abstract: This study aimed to identify the most cost-effective vancomycin dosage regimen to treat ventilator-associated pneumonia (VAP) in critically ill patients infected with “minimum inhibitory concentration (MIC) Creep” Methicillin-resistant Staphylococcus aureus (MRSA). Decision tree analysis with… read more here.

Keywords: ventilator associated; dosage; analysis; dosage regimen ... See more keywords