Assessment of micafungin loading dosage regimens against Candida spp. in ICU patients by Monte Carlo simulations
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DOI: 10.1007/s00228-020-02840-0
Abstract: To assess the efficacy of loading dose on micafungin by simulating different dosage regimens. A published study of micafungin in ICU patients was employed to simulate nine different dosage regimens which were sorted out three… read more here.
Keywords: auc mic; candida spp; icu patients; dosage ... See more keywords
Population Pharmacokinetics/Pharmacodynamics and Clinical Outcomes of Meropenem in Critically Ill Patients
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DOI: 10.1128/aac.00845-22
Abstract: Several pathophysiological changes can alter meropenem pharmacokinetics in critically ill patients, thereby increasing the risk of subtherapeutic concentrations and affecting therapeutic outcomes. This study aimed to characterize the population pharmacokinetic (PPK) parameters of meropenem, evaluate… read more here.
Keywords: ill patients; ppk parameters; critically ill; population ... See more keywords
Pharmacokinetic/Pharmacodynamic Simulations of Cost-Effective Dosage Regimens of Ceftolozane-Tazobactam and Ceftazidime-Avibactam in Patients with Renal Impairment
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DOI: 10.1128/aac.02104-21
Abstract: The pharmacokinetics of ceftolozane-tazobactam (TOL-TAZ) and ceftazidime-avibactam (CEF-AVI) is influenced by renal function. Application of recommended dosages in patients with renal impairment requires the use of fractions of the full dose, as only one dosage… read more here.
Keywords: ceftolozane tazobactam; ceftazidime avibactam; renal impairment; dosage regimens ... See more keywords