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   Articles with "dosage sensitive" as a keyword



Tb3+-Based Off-On Fluorescent Platform for Multicolor and Dosage-Sensitive Visualization of Bacterial Spore Marker.

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recommendations! Published in 2023 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.3c01542

Abstract: Developing a novel strategy for the sensitive and rapid detection of pathogenic bacterial spores in field or on-site settings will be helpful in minimizing their potential threats to human health, environmental safety, and food safety.… read more here.

Keywords: bacterial spore; dosage sensitive; dpa; tb3 ... See more keywords

Efficient CNV breakpoint analysis reveals unexpected structural complexity and correlation of dosage‐sensitive genes with clinical severity in genomic disorders

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recommendations! Published in 2017 at "Human Molecular Genetics"

DOI: 10.1093/hmg/ddx102

Abstract: &NA; Genomic disorders are the clinical conditions manifested by submicroscopic genomic rearrangements including copy number variants (CNVs). The CNVs can be identified by array‐based comparative genomic hybridization (aCGH), the most commonly used technology for molecular… read more here.

Keywords: structural complexity; genomic disorders; dosage sensitive; cnv breakpoint ... See more keywords

Evolution of Dosage-Sensitive Genes by Tissue-Restricted Expression Changes

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recommendations! Published in 2024 at "Genome Biology and Evolution"

DOI: 10.1101/2024.10.17.618887

Abstract: Dosage-sensitive genes have characteristic patterns of evolution that include being refractory to small-scale duplication, depleted on human benign copy number variants (CNVs) and enriched on pathogenic CNVs. This intolerance to copy number change is likely… read more here.

Keywords: evolution; dosage sensitive; dosage; sensitive genes ... See more keywords

Abstract NBT102: RBX1 Is an Indispensable, Dosage-Sensitive Regulator of Perinatal Heart Development

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recommendations! Published in 2025 at "Circulation Research"

DOI: 10.1161/res.137.suppl_1.nbt102

Abstract: Disrupting the tightly regulated process of cardiac development can lead to congenital heart diseases, yet the role of posttranslational mechanisms remains largely overlooked. Here, we uncover a novel role for Cullin-RING ubiquitin E3 ligases (CRLs)… read more here.

Keywords: dosage sensitive; heart; sensitive regulator; development ... See more keywords