Efficacy and Safety Considerations With Dose-Reduced Direct Oral Anticoagulants: A Review.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2022.1292
Abstract: Importance Dose-reduced regimens of direct oral anticoagulants (DOACs) may be used for 2 main purposes: dose-adjusted treatment intended as full-intensity anticoagulation (eg, for stroke prevention in atrial fibrillation [AF] in patients requiring dose reduction) or… read more here.
Keywords: dose adjusted; low intensity; treatment; dose reduced ... See more keywords
Impact of liver fibrosis and clinical characteristics on dose-adjusted serum methadone concentrations
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Addictive Diseases"
DOI: 10.1080/10550887.2022.2057140
Abstract: Abstract Background There is limited knowledge on the causes of large variations in serum methadone concentrations and dose requirements. Objectives We investigated the impact of the degree of liver fibrosis on dose-adjusted steady-state serum methadone… read more here.
Keywords: adjusted serum; liver fibrosis; serum methadone; dose adjusted ... See more keywords
Dose-adjusted EPOCH-R vs. R-CHOP in frontline management of Waldeyer's ring diffuse large B-cell lymphoma: a retrospective study from a single institution
Sign Up to like & getrecommendations! Published in 2023 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000002593
Abstract: Abstract Background: To compare the efficacy and safety of dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin plus rituximab (DA-EPOCH-R) with standard rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in Waldeyer's ring diffuse large B-cell lymphoma… read more here.
Keywords: waldeyer ring; dose adjusted; group; large cell ... See more keywords
Venetoclax + hypomethylating agents combined with dose-adjusted HAG for relapsed/refractory acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2020 at "Medicine"
DOI: 10.1097/md.0000000000023265
Abstract: Abstract Rationale: Some acute myeloid leukemia (AML) patients are unresponsive to treatment or have remission followed by worsening of disease (known as relapsed/refractory AML [R/RAML]) after standardized treatment. The CAG/HAG regimen is not often used… read more here.
Keywords: myeloid leukemia; acute myeloid; treatment; case ... See more keywords
Dose adjusted‐EPOCH‐R and mediastinal disease may improve outcomes for patients with gray‐zone lymphoma
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Haematology"
DOI: 10.1111/bjh.14226
Abstract: in 7 5% of cells, del(13q) in 45% of cells and was negative for t(11;14). The patient received a single dose of bendamustine and rituximab, however B-cell lymphocytosis persisted. Upon completion of the 28-d cycle,… read more here.
Keywords: epoch mediastinal; dose adjusted; mediastinal disease; disease ... See more keywords
Dose‐adjusted EPOCH and rituximab (DA‐EPOCH‐R) in older patients with high‐risk aggressive diffuse large B‐cell lymphoma: A real‐life multicenter study by the Croatian Cooperative Group for Hematologic diseases (KroHem)
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Haematology"
DOI: 10.1111/ejh.13957
Abstract: Dose‐adjusted EPOCH and rituximab (DA‐EPOCH‐R) is a regimen used for the treatment of high‐risk diffuse large B‐cell lymphoma (DLBCL) designed to overcome resistance to standard R‐CHOP by combining prolonged exposure of lymphoma cells to cytotoxic… read more here.
Keywords: lymphoma; high risk; rituximab epoch; dose adjusted ... See more keywords
Dose‐adjusted EPOCH‐R is a safe and well tolerated outpatient treatment regimen in double‐hit lymphoma
Sign Up to like & getrecommendations! Published in 2022 at "Internal Medicine Journal"
DOI: 10.1111/imj.15747
Abstract: Double‐hit lymphoma (DHL) is an aggressive subtype of high‐grade B‐cell lymphoma with inferior prognosis using standard dose chemotherapy. Controversy remains whether more intensive chemotherapy regimens such as dose‐adjusted etoposide, prednisolone, vincristine, cyclophosphamide, doxorubicin and rituximab… read more here.
Keywords: hit lymphoma; double hit; dose adjusted; adjusted epoch ... See more keywords
Reversal of immune-checkpoint inhibitor fulminant myocarditis using personalized-dose-adjusted abatacept and ruxolitinib: proof of concept
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004699
Abstract: Immune-checkpoint inhibitors (ICI) have revolutionized cancer therapy but are associated with infrequent but lethal myocarditis, for which management remains uncertain. Abatacept, a CTLA-4 fusion protein targeting CD86 on antigen presenting cells and leading to global… read more here.
Keywords: adjusted abatacept; immune checkpoint; myocarditis; myocarditis using ... See more keywords
Medications Used Routinely in Primary Care to be Dose-Adjusted or Avoided in People With Chronic Kidney Disease: Results of a Modified Delphi Study
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Pharmacotherapy"
DOI: 10.1177/1060028019897371
Abstract: Background: Chronic kidney disease (CKD) affects up to 18% of those over the age of 65 years. Potentially inappropriate medication prescribing in people with CKD is common. Objectives: Develop a pragmatic list of medications used… read more here.
Keywords: dose adjusted; chronic kidney; primary care; adjusted avoided ... See more keywords
Dose-adjusted (DA)-EPOCH-R with high-dose methotrexate (HD-MTX) for newly diagnosed stage II-IV CD5-positive diffuse large B-cell Iymphoma (CD5+ DLBCL): Primary analysis of PEARL5 study.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.7561
Abstract: 7561Background: CD5+ DLBCL comprises 5-10% of DLBCL and is characterized by various aggressive clinical features and frequent CNS relapse. Our previous retrospective study (Miyazaki et al. Ann Onco... read more here.
Keywords: cd5; dose adjusted; cd5 dlbcl; study ... See more keywords
Transition of dose-adjusted EPOCH therapy into the outpatient healthcare setting: Quality and cost considerations for outpatient treatment.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.30_suppl.110
Abstract: 110 Background: Dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin (EPOCH)-containing regimens are frequently utilized in lymphoma, however, outpatient EPOCH or modified inpatient/outpatient EPOCH has not been described extensively. We transitioned inpatient EPOCH to the outpatient setting… read more here.
Keywords: quality; dose adjusted; outpatient setting; outpatient ... See more keywords