Administration of anesthetic drugs according to pharmacological principles: are we heading in the right direction?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Monitoring and Computing"
DOI: 10.1007/s10877-019-00376-y
Abstract: In this edition of JCMCI, two related papers have been published respectively exploring the feasibility [1] and the acceptability [2] of a new algorithm for the optimization of intravenous propofol titration in combination with remifentanil… read more here.
Keywords: algorithm; effect; effect site; anesthetic drugs ... See more keywords
A brief ICU residents’ guide: Pharmacotherapy, pharmacokinetic aspects and dose adjustments in critically ill adult patients admitted to ICU
Sign Up to like & getrecommendations! Published in 2021 at "Trends in Anaesthesia and Critical Care"
DOI: 10.1016/j.tacc.2021.05.004
Abstract: Abstract Critical illness could result in altered pharmacokinetic profiles of many commonly administered medications in ICU settings. Pharmacokinetic, which consists of a multistage process containing absorption, distribution, metabolism, and elimination, could be significantly altered in… read more here.
Keywords: ill patients; pharmacokinetic aspects; critically ill; dose adjustments ... See more keywords
Prevention of Venous Thromboembolism in Microvascular Surgery Patients Using Weight-Based Unfractionated Heparin Infusions.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of reconstructive microsurgery"
DOI: 10.1055/s-0041-1735225
Abstract: BACKGROUND Unfractionated heparin infusions are commonly used in microvascular surgery to prevent microvascular thrombosis. Previously, fixed-dose heparin infusions were believed to provide sufficient venous thromboembolism (VTE) prophylaxis; however, we now know that this practice is… read more here.
Keywords: heparin infusions; heparin; microvascular surgery; unfractionated heparin ... See more keywords
Dofetilide Dose Reductions and Discontinuation in Obese Compared with Nonobese Patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000001353
Abstract: Abstract: Dofetilide is an antiarrhythmic agent and primarily eliminated renally. Initial dosing is determined by creatinine clearance, calculated by total body weight in the Cockcroft–Gault equation. To date, there is no evidence comparing the dosing… read more here.
Keywords: adjustments compared; body weight; nonobese patients; dose reductions ... See more keywords
Quetiapine Dose Adjustments in Pregnant and Postpartum Women With Bipolar Disorder.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Psychopharmacology"
DOI: 10.1097/jcp.0000000000000820
Abstract: and rapidity of their improvement upon discontinuation of clozapine, adds to the extant literature on this topic. Rather than increasing clozapine dosage to target ongoing symptoms that could be classified as OCS in individuals with… read more here.
Keywords: quetiapine dose; adjustments pregnant; pregnant postpartum; women bipolar ... See more keywords
Comment on Delanaye et al: Future perspectives regarding kidney function estimates and dose adjustments
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.15195
Abstract: observational indicate prescribing is approximately of all of and hospitalizations. About 40% of all should be according to renal function, 2 and a Swedish study concluded that one third of all adverse drug reactions leading… read more here.
Keywords: function; kidney function; dosing guidelines; comment delanaye ... See more keywords
Real‐world dose adjustments of biologic treatments in psoriasis and their economic impact: a Swedish national population study
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Dermatology"
DOI: 10.1111/ced.15288
Abstract: To date, evidence on the dose adjustments of biologics in the real‐world treatment of psoriasis is limited. However, dose adjustments may have important clinical and economic implications. read more here.
Keywords: world dose; adjustments biologic; biologic treatments; dose adjustments ... See more keywords
VANCOmycin dose adjustments comparing trough levels to the ratio of the area under de curve to the minimum inhibitory concentration method using a BAYESian approach: A feasibility study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.13818
Abstract: The latest published guidelines advocate for the area under the concentration‐time curve to minimal inhibitory concentration (AUC0‐24h/MIC) estimated with bayesian calculations. This recommended pharmacokinetic monitoring transition is not based on randomized controlled prospective data. read more here.
Keywords: inhibitory concentration; curve; area; vancomycin dose ... See more keywords
Effect of Dose Adjustments on the Safety and Efficacy of Afatinib in Chinese Patients with EGFR-Mutated Non-Small Cell Lung Cancer Who Participated in the LUX-Lung Clinical Trial Program
Sign Up to like & getrecommendations! Published in 2020 at "OncoTargets and therapy"
DOI: 10.2147/ott.s273866
Abstract: Background Post hoc analysis of the LUX-Lung 3 and 6 (LL3/6) Phase III trials showed that tolerability-guided dose-adjustments of afatinib reduced treatment-related adverse events (TRAEs) without affecting progression-free survival (PFS) in patients with epidermal growth… read more here.
Keywords: lux lung; dose reduction; dose adjustments; tolerability guided ... See more keywords
Model-Based Biomarker Selection for Dose Individualization of Tyrosine-Kinase Inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.00316
Abstract: Tyrosine-kinase inhibitors (TKIs) demonstrate high inter-individual variability with respect to safety and efficacy and would therefore benefit from dose or schedule adjustments. This study investigated the efficacy, safety, and economical aspects of alternative dosing options… read more here.
Keywords: kinase inhibitors; model based; biomarker; dose individualization ... See more keywords
Pharmacogenetic Dose Modeling Based on CYP2C19 Allelic Phenotypes
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14122833
Abstract: Pharmacogenetic variability in drug metabolism leads to patient vulnerability to side effects and to therapeutic failure. Our purpose was to introduce a systematic statistical methodology to estimate quantitative dose adjustments based on pharmacokinetic differences in… read more here.
Keywords: based cyp2c19; cyp2c19 allelic; modeling based; dose modeling ... See more keywords