Effect of Cytochrome P450 and ABCB1 Polymorphisms on Imatinib Pharmacokinetics After Single-Dose Administration to Healthy Subjects
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DOI: 10.1007/s40261-020-00921-7
Abstract: Validated genomic biomarkers for oncological drugs are expanding to improve targeted therapies. Pharmacogenetics research focusing on the mechanisms underlying imatinib suboptimal response might help to explain the different treatment outcomes and drug safety profiles. To… read more here.
Keywords: administration healthy; healthy subjects; dose administration; cytochrome p450 ... See more keywords
A phase 1b randomized, placebo‐controlled clinical trial with SNF472 in haemodialysis patients
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DOI: 10.1111/bcp.13863
Abstract: SNF472 is a calcification inhibitor that is being studied as a novel treatment for calciphylaxis and cardiovascular calcification (CVC). A first study showed acceptable safety and tolerability in a single ascending dose administration in healthy… read more here.
Keywords: haemodialysis patients; trial; haemodialysis; phase randomized ... See more keywords
Assessing the Safety, Tolerability, Pharmacokinetics, and Biodistribution of Novel Oral Formulations of Amphotericin B following Single- and Multiple-Dose Administration to Beagle Dogs
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DOI: 10.1128/aac.01111-20
Abstract: The purpose of this study was to assess the safety, tolerability, pharmacokinetics (PK), and biodistribution of novel oral amphotericin B (AmpB) formulations following single- and multiple-oral-dose administration to healthy beagle dogs. The liquid formulation of… read more here.
Keywords: single multiple; capsule formulations; dose administration; novel oral ... See more keywords
Telmisartan Tablets Repackaged into Dose Administration Aids: Physicochemical Stability under Tropical Conditions
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DOI: 10.3390/pharmaceutics14081667
Abstract: Dose administration aids (DAAs) are commonly used to assist patients with chronic disease to manage multiple medications and thus improve adherence. Several brands of telmisartan, commonly prescribed for hypertension, are available in Australia. Manufacturer’s storage… read more here.
Keywords: tropical conditions; dose administration; tablets repackaged; administration aids ... See more keywords