Molecular determinants of response to high dose androgen therapy in prostate cancer.
Sign Up to like & getrecommendations! Published in 2019 at "JCI insight"
DOI: 10.1172/jci.insight.129715
Abstract: Clinical trials of high-dose androgen therapy for prostate cancer have shown promising efficacy but are limited by lack of criteria to identify likely responders. To elucidate factors that govern the growth-repressive effects of high-dose androgens… read more here.
Keywords: androgen; high dose; dose androgen; prostate cancer ... See more keywords
Preclinical discovery and validation of high-dose androgen drug synergies for the treatment of prostate cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.6_suppl.202
Abstract: 202Background: Recent clinical studies have taken advantage of the dichotomous ability of androgen receptor signaling to elicit growth-suppressive and differentiating effects by giving hyper-physiological levels of testosterone. This approach has demonstrated safety, improved quality of… read more here.
Keywords: high dose; preclinical discovery; treatment; dose androgen ... See more keywords