A randomized, controlled, phase 2 trial of nivolumab plus standard-dose or low-dose bevacizumab for recurrent glioblastoma (NAVAL).
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.16_suppl.2072
Abstract: 2072 Background: PD-1/PD-L1 inhibition has demonstrated limited efficacy for recurrent glioblastoma (rGBM) across prior RCTs. VEGF, a proangiogenic factor upregulated in rGBM, contributes to tumor-associated immunosuppression. Preclinical and observational clinical data indicate a potential dose-dependent… read more here.
Keywords: low dose; dose; standard dose; dose arm ... See more keywords
Short-course hypofractionated radiotherapy of 4 Gy per fraction for limited-stage small cell lung cancer: a randomized pilot trial
Sign Up to like & getrecommendations! Published in 2025 at "Translational Lung Cancer Research"
DOI: 10.21037/tlcr-2025-281
Abstract: Background Local-regional relapse remains high after the standard radiotherapy regimen for limited-stage small cell lung cancer (LS-SCLC). Short-course hypofractionated radiotherapy may improve disease control. In this single-institution open-label pilot trial, we aimed to explore the… read more here.
Keywords: dose arm; lung cancer; hypofractionated radiotherapy; course hypofractionated ... See more keywords