Development and Validation of RP-LC Method for the Simultaneous Determination of Simvastatin and Ezetimibe in Fixed-Dose Combination Tablets and in Rabbit Serum
Sign Up to like & getrecommendations! Published in 2018 at "Chromatographia"
DOI: 10.1007/s10337-018-3642-x
Abstract: Combined drug therapy which is based on the co-administration of two or more drugs, have been used for a long time, to treat diseases. In this study, a simple, selective and rapid RP-LC method has… read more here.
Keywords: dose combination; tablets rabbit; method; fixed dose ... See more keywords
Formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori coccon shell extract, Flaxseed oil and coenzyme Q10 against doxorubicin induced cardiomyopathy in rats
Sign Up to like & getrecommendations! Published in 2019 at "Oriental Pharmacy and Experimental Medicine"
DOI: 10.1007/s13596-019-00360-6
Abstract: The present study aims at formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori (Abresham) extract, Flaxseed oil and coenzyme Q10 (CoQ10) against doxorubicin induced myocardial toxicity in rats. Formulation (emulsion) was… read more here.
Keywords: doxorubicin induced; dose combination; flaxseed oil; fixed dose ... See more keywords
The clinical implications of triple therapy in fixed-dose combination in COPD: from the trial to the patient
Sign Up to like & getrecommendations! Published in 2020 at "Archivos De Bronconeumologia"
DOI: 10.1016/j.arbr.2020.02.002
Abstract: The emergence of a fixed-dose combination (FDC) of a long-acting β2-agonists (LABAS), a long-acting anticholinergic agent (LAMA), and an inhaled corticosteroid (ICS) in a single inhalation device has changed the approach to inhaled therapy. Although… read more here.
Keywords: fixed dose; dose combination; efficacy; triple therapy ... See more keywords
Efficacy and safety of a four-drug fixed-dose combination regimen versus separate drugs for treatment of pulmonary tuberculosis: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2017 at "Brazilian Journal of Microbiology"
DOI: 10.1016/j.bjm.2016.12.003
Abstract: Introduction Tuberculosis, particularly multi-drug-resistant tuberculosis, is a major cause of morbidity and mortality worldwide. To the best of our knowledge, however, no study to date has assessed the combined use of the four available drugs… read more here.
Keywords: dose combination; four drug; treatment; drug ... See more keywords
Bioequivalence Study of a New Fixed-dose Combination Tablet Containing S-Amlodipine Nicotinate and Olmesartan Medoxomil in Healthy Korean Male Subjects.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2017.05.355
Abstract: PURPOSE A fixed-dose combination (FDC) pill of amlodipine (relatively old calcium channel blocker as dihydropyridine) and olmesartan (relatively new angiotensin II receptor blocker) is used for hypertension that is not adequately controlled with a single-formulation… read more here.
Keywords: bioequivalence; dose combination; product; olmesartan medoxomil ... See more keywords
Comparison of Pharmacokinetics and Safety of a Fixed-dose Combination of Rosuvastatin and Ezetimibe Versus Separate Tablets in Healthy Subjects.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2017.07.038
Abstract: PURPOSE Rosuvastatin and ezetimibe are concomitantly used for dyslipidemia treatment. Compared with separate tablets, fixed-dose combination (FDC) tablets of rosuvastatin/ezetimibe could increase patient compliance. The aim of this study was to compare the pharmacokinetic (PK)… read more here.
Keywords: rosuvastatin ezetimibe; dose combination; rosuvastatin; study ... See more keywords
Persistence of GLP-1 RA in combination with basal insulin among adults with Type 2 diabetes in Canada.
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes research and clinical practice"
DOI: 10.1016/j.diabres.2021.108920
Abstract: AIMS The purpose of this study is to assess the persistence of Canadians with Type 2 diabetes mellitus (T2D) on loose-dose combination treatment (i.e., administered by separate devices) with a glucagon-like peptide 1 receptor agonist… read more here.
Keywords: combination; dose combination; persistence; glp ... See more keywords
Topical Fixed-Dose Combinations: Current in vitro methodologies for pre-clinical development.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2022.121621
Abstract: The combination of two or more active pharmaceutical ingredients in the same dosage form - fixed-dose combination products - for topical administration represents a promising therapeutic approach for treating several pathologies, including pain. The pre-clinical… read more here.
Keywords: pre clinical; fixed dose; clinical development; dose combination ... See more keywords
Preparation and In vitro characterization of a novel self-nano emulsifying drug delivery system for a fixed-dose combination of candesartan cilexetil and hydrochlorothiazide
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2021.102320
Abstract: Abstract A fixed-dose combination of Candesartan cilexetil (CAN) and Hydrochlorothiazide (HCTZ) is commonly used for the management of hypertension. CAN (BCS class II) and HCTZ (BCS class IV) suffer from inadequate oral bioavailability. Herein, the… read more here.
Keywords: drug; fixed dose; drug delivery; dose combination ... See more keywords
Tackling quantitative polymorphic analysis through fixed-dose combination tablets production. Pyrazinamide polymorphic assessment.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113786
Abstract: Pyrazinamide (PZA), Rifampicin (RIF), Isoniazid (ISH) and Ethambutol (ETB) form the core for the treatment of Tuberculosis, today a devastating disease in low-income populations around the world. These drugs are usually administrated by fixed-dose combination… read more here.
Keywords: fdc tablets; drug substance; dose combination; form ... See more keywords
Fixed-dose combination therapy and polypills to prevent and treat CVD
Sign Up to like & getrecommendations! Published in 2021 at "Nature Reviews Cardiology"
DOI: 10.1038/s41569-021-00614-4
Abstract: In the QUARTET trial, initial treatment with a single pill containing quarter doses of four antihypertensive drugs achieved and maintained a greater blood-pressure-lowering effect than initial monotherapy with full-dose irbesartan. read more here.
Keywords: therapy polypills; dose combination; polypills prevent; fixed dose ... See more keywords