From ‘fixed dose combinations’ to ‘a dynamic dose combiner’: 3D printed bi‐layer antihypertensive tablets
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.07.045
Abstract: ABSTRACT There is an increased evidence for treating hypertension by a combination of two or more drugs. Increasing the number of daily intake of tablets has been reported to negatively affect the compliance of patients.… read more here.
Keywords: dose combinations; combinations dynamic; combiner printed; dose combiner ... See more keywords
Treatment of hepatitis C with new fixed dose combinations
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2017.1346609
Abstract: ABSTRACT Introduction: The advent of oral direct-acting antivirals (DAA) has revolutionized the hepatitis C virus (HCV) therapeutic landscape providing cure rates over 90%. However, a subset of patients remains at higher risk for treatment failure,… read more here.
Keywords: treatment; dose combinations; treatment hepatitis; fixed dose ... See more keywords
P4561Patients adherence with fixed dose combinations of renin-angiotensin-aldosterone system inhibitors in hypertension
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz745.0952
Abstract: The latest ESC/ESH guidelines recommended fixed dose combinations (FDC) for first therapy in hypertension. Preferred two-drug combinations are a RAS (renin–angiotensin system) blocker with a CCBs (calcium channel blockers) or a diuretic. There are no… read more here.
Keywords: one year; dose combinations; renin angiotensin; hypertension ... See more keywords
Evergreened drugs or evergreened profits?
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DOI: 10.1111/jep.13695
Abstract: BACKGROUND Branded drugs contribute disproportionately to high prescription drug spending. Pharmaceutical companies utilize patent extension "evergreening" techniques that contribute to high drug costs. AIMS This article describes various patent extension techniques and analyzes the tactic… read more here.
Keywords: patent extension; individual constituents; fixed dose; dose combinations ... See more keywords
Testing multiple dose combinations in clinical trials
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DOI: 10.1177/0962280219871969
Abstract: Drug combination trials are often motivated by the fact that individual drugs target the same disease but via different routes. A combination of such drugs may then have an overall better effect than the individual… read more here.
Keywords: combination; testing multiple; new approaches; dose combinations ... See more keywords
Treatment persistence and adherence in people with type 2 diabetes switching to iGlarLixi vs free-dose combinations of basal insulin and glucagon-like peptide 1 receptor agonist.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of managed care & specialty pharmacy"
DOI: 10.18553/jmcp.2022.28.9.958
Abstract: BACKGROUND: Fixed-ratio combinations of basal insulin (BI) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have greater simplicity of administration with expected improved adherence/persistence with therapy, but real-world data are lacking. OBJECTIVE: To compare medication persistence,… read more here.
Keywords: persistence; iglarlixi free; glp ras; dose ... See more keywords
Preformulation Studies of Ezetimibe-Simvastatin Solid Dispersions in the Development of Fixed-Dose Combinations
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DOI: 10.3390/pharmaceutics14050912
Abstract: Two active pharmaceutical ingredients (APIs) with limited solubility, simvastatin and ezetimibe, prepared as a drug-drug solid dispersion (SD) was evaluated for physicochemical, microstructural, and aqueous dissolution properties. The simvastatin-ezetimibe SD was prepared using the co-grinding… read more here.
Keywords: ezetimibe simvastatin; development; fixed dose; preformulation studies ... See more keywords
Prescribing Trends and Rationality of Fixed Dose Combinations in a Tertiary Care Hospital: An Observational Study
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DOI: 10.36468/pharmaceutical-sciences.680
Abstract: This investigation aimed to review the prescribing trends of fixed dose combinations, to assess their rationality and inclusion in essential medicines list and national list of essential medicines. Medication charts of 1000 in-patients from general… read more here.
Keywords: essential medicines; dose combinations; rationality; list ... See more keywords
Irrational ophthalmic fixed-dose combinations for dry eye syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Indian Journal of Ophthalmology"
DOI: 10.4103/ijo.ijo_1169_22
Abstract: Dry eye syndrome (DES) is a common disorder with rising incidence due to increased use of digital devices. While multiple treatment options are available, some are not efficacious or sometimes even safe for use in… read more here.
Keywords: eye syndrome; dry eye; fixed dose; dose combinations ... See more keywords