High-Dose Dexamethasone and Oxygen Support Strategies in Intensive Care Unit Patients With Severe COVID-19 Acute Hypoxemic Respiratory Failure: The COVIDICUS Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2022.2168
Abstract: Importance The benefit of high-dose dexamethasone and oxygenation strategies vs standard of care for patients with severe acute hypoxemic respiratory failure (AHRF) caused by COVID-19 pneumonia is debated. Objectives To assess the benefit of high-dose… read more here.
Keywords: dose dexamethasone; trial; care; high dose ... See more keywords
Low frequency of CD3+CD4+CD161+ T cells correlates with the occurrence of infections in refractory/relapsed multiple myeloma patients receiving lenalidomide plus low-dose dexamethasone treatment
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Hematology"
DOI: 10.1007/s00277-018-3401-y
Abstract: The aim of this study was to explore the predictive implications of the composition of immune cell populations prior to lenalidomide plus high-dose dexamethasone (Len-Dex) initiation for the occurrence of infections. We prospectively examined immune… read more here.
Keywords: cd3 cd4; dex; lenalidomide plus; occurrence infections ... See more keywords
Influence of long-term, high-dose dexamethasone administration on proliferation and apoptosis in porcine hepatocytes.
Sign Up to like & getrecommendations! Published in 2017 at "Research in veterinary science"
DOI: 10.1016/j.rvsc.2017.03.018
Abstract: The aim of this study was to examine the influence of long-term, high-dose dexamethasone administration on the liver, with particular emphasis on hepatocyte proliferation and apoptosis, using a swine model. The study included 48 large,… read more here.
Keywords: dexamethasone; dose dexamethasone; dexamethasone administration; high dose ... See more keywords
Influence of dental restoration under general anaesthesia on the low-dose dexamethasone suppression test in dogs.
Sign Up to like & getrecommendations! Published in 2020 at "Research in veterinary science"
DOI: 10.1016/j.rvsc.2020.01.002
Abstract: It was the aim of the study to assess the impact of a minor surgical intervention under general anaesthesia on results of a low-dose dexamethasone suppression test (LDDST) in dogs. Five clinically healthy dogs underwent… read more here.
Keywords: low dose; general anaesthesia; dose dexamethasone; suppression test ... See more keywords
High dose dexamethasone as an alternative rescue therapy for active bleeding in children with chronic ITP: clinical and immunological effects
Sign Up to like & getrecommendations! Published in 2018 at "Platelets"
DOI: 10.1080/09537104.2018.1530347
Abstract: Abstract High-dose dexamethasone (HD-DXM) is debated as a second-line therapy for chronic Immune thrombocytopenia (ITP) in children. The aim of this study is to evaluate the efficacy and safety of HD-DXM as an emergency therapy… read more here.
Keywords: high dose; chronic itp; dose dexamethasone; children chronic ... See more keywords
Dexamethasone-sparing regimen is an effective and safe alternative in overall antiemetic protection
Sign Up to like & getrecommendations! Published in 2019 at "Medicine"
DOI: 10.1097/md.0000000000017364
Abstract: Abstract Objective: We performed a meta-analyisis to evaluate the efficacy of maintenance dexamethasone against acute or delayed chemotherapy-induced nausea and vomiting (CINV) in patients receiving moderately or highly emetic risk chemotherapy regimen. Methods: PubMed, Embase,… read more here.
Keywords: dexamethasone; dose dexamethasone; single dose; maintenance dexamethasone ... See more keywords
Should dexamethasone alone or in combination be the initial steroid for adult ITP: Still a relevant question
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Haematology"
DOI: 10.1111/bjh.18398
Abstract: Corticosteroids are used in first‐line treatment in newly diagnosed immune thrombocytopenia. The goal of treatment is primarily to decrease autoantibody‐mediated platelet clearance. Ideally initial treatment would not just increase the platelet count but also provide… read more here.
Keywords: dose dexamethasone; dexamethasone alone; platelet; treatment ... See more keywords
High- Versus Low-Dose Dexamethasone for the Treatment of COVID-19-Related Acute Respiratory Distress Syndrome: A Multicenter, Randomized Open-Label Clinical Trial
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Intensive Care Medicine"
DOI: 10.1177/08850666211066799
Abstract: Objective To determine whether high-dose dexamethasone increases the number of ventilator-free days (VFD) among patients with acute respiratory distress syndrome (ARDS) caused by COVID-19. Design Multicenter, randomized, open-label, clinical trial. Participants Consecutive patients with confirmed… read more here.
Keywords: trial; low dose; treatment; dose dexamethasone ... See more keywords
MOR202 with low-dose dexamethasone (Dex) and in combination with pomalidomide/dex and lenalidomide/dex in relapsed or refractory multiple myeloma (RRMM): Interim analysis of a phase I/IIa dose-escalation study.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.8024
Abstract: 8024Background: CD38 is a type II transmembrane glycoprotein expressed by MM cells. MOR202, a human IgG1 CD38 monoclonal antibody, has shown high single-agent activity in preclinical models of MM a... read more here.
Keywords: mor202 low; low dose; dex; dexamethasone dex ... See more keywords
Pomalidomide (POM), bortezomib, and low‐dose dexamethasone (PVd) vs bortezomib and low-dose dexamethasone (Vd) in lenalidomide (LEN)-exposed patients (pts) with relapsed or refractory multiple myeloma (RRMM): Phase 3 OPTIMISMM trial.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.8001
Abstract: 8001Background: POM, a standard-of-care treatment (Tx) in RRMM, has demonstrated synergistic anti-myeloma activity with dexamethasone (DEX) and proteasome inhibitors (PIs). POM + DEX is indicated f... read more here.
Keywords: low dose; dose dexamethasone; bortezomib low; dexamethasone ... See more keywords
A phase III randomized, open label, multicenter study comparing isatuximab, pomalidomide, and low-dose dexamethasone versus pomalidomide and low-dose dexamethasone in patients with relapsed/refractory multiple myeloma (RRMM).
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.8004
Abstract: 8004 Background: The primary objective of this phase 3 trial was to demonstrate progression free survival (PFS) improvement of isatuximab (Isa), a novel anti-CD38 monoclonal antibody, combined with pomalidomide (P)/dexamethasone (d) versus (vs) Pd. Methods:… read more here.
Keywords: pomalidomide low; dose dexamethasone; isapd; low dose ... See more keywords