Net clinical benefit of a reduced dose of DOACs in non-valvular atrial fibrillation: a meta-analysis of randomized trials.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105902
Abstract: BACKGROUND In standard dosing, direct Oral Anticoagulants (DOACs) are used as an alternative to warfarin to prevent ischemic stroke and systemic embolism in non-valvular Atrial Fibrillation (AF). However, randomized comprehensive evidence considering the efficacy and… read more here.
Keywords: clinical benefit; benefit; net clinical; randomized trials ... See more keywords
Direct Oral Anticoagulants versus Warfarin in Patients with Atrial Fibrillation: Patient-Level Network Meta-Analyses of Randomized Clinical Trials with Interaction Testing by Age and Sex.
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DOI: 10.1161/circulationaha.121.056355
Abstract: Background: Direct oral anticoagulants (DOACs) are preferred over warfarin for stroke prevention in atrial fibrillation (AF). Meta-analyses using individual patient data offer significant advantages over study-level data. Methods: We used individual patient data from the… read more here.
Keywords: standard dose; interaction; dose doacs; dose ... See more keywords
Direct Oral Anticoagulants Versus Warfarin Across the Spectrum of Kidney Function: Patient-Level Network Meta-Analyses From COMBINE AF
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DOI: 10.1161/circulationaha.122.062752
Abstract: Background: There is uncertainty surrounding the use of direct oral anticoagulants (DOACs) in patients with kidney dysfunction. Methods: Using the COMBINE AF (A Collaboration Between Multiple Institutions to Better Investigate Non-Vitamin K Antagonist Oral Anticoagulant… read more here.
Keywords: dose doacs; standard dose; crcl; hazard ... See more keywords
Off-label dose direct oral anticoagulants and clinical outcomes in Asian patients with atrial fibrillation: A new evidence of Asian dose.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of cardiology"
DOI: 10.2139/ssrn.4112820
Abstract: AIM This study aimed to evaluate the label compliance of DOACs in the Chinese AF population and explore the relationship between inappropriate DOACs dosage and clinical results. METHODS AND RESULTS This is a retrospective multicenter… read more here.
Keywords: dose doacs; dose; asian patients; label dose ... See more keywords