Neural-network dose-prediction for rectal spacer stratification in dose-escalated prostate radiotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Medical physics"
DOI: 10.1002/mp.15575
Abstract: PURPOSE To develop a knowledge-based decision-support system capable of stratifying patients for rectal spacer (RS) insertion based on neural-network-predicted rectal dose, reducing the need for time- and resource-intensive radiotherapy (RT) planning. METHODS Forty four patients… read more here.
Keywords: risk; dose; network; neural network ... See more keywords
Image-guided dose-escalated radiation therapy for localized prostate cancer with helical tomotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Strahlentherapie und Onkologie"
DOI: 10.1007/s00066-019-01562-2
Abstract: Purpose To evaluate treatment outcomes for patients with localized prostate cancer who were treated with dose-escalated primary image-guided radiation therapy (IGRT). Methods We retrospectively analyzed 88 consecutive patients treated using helical tomotherapy with daily megavoltage… read more here.
Keywords: risk; toxicity; dose escalated; cancer ... See more keywords
Combination dose-escalated hydroxyurea and transfusion: an approach to conserve blood during the COVID-19 pandemic
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2020006582
Abstract: Nickel et al describe a single-arm trial using dose-escalated hydroxyurea and regular transfusions to prevent complications of sickle cell anemia. Preliminary results suggest that a reduction in volume of red cell requirements may be achievable. read more here.
Keywords: combination dose; transfusion approach; hydroxyurea transfusion; blood ... See more keywords
Validation of the decipher genomic classifier (GC) in SAKK 09/10: A phase III randomized trial of dose-escalated salvage radiotherapy (SRT) after radical prostatectomy (RP).
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.5010
Abstract: 5010 Background: GC has been shown to independently prognosticate outcomes in prostate cancer. Herein, we validate the GC in a European randomized phase III trial of dose escalated SRT after RP. Methods: SAKK 09/10 (NCT01272050)… read more here.
Keywords: phase iii; adt; salvage; trial dose ... See more keywords
PORTOS gene signature as a predictor of risk of adverse events after dose-escalated vs. lower-dose prostate radiation therapy in NRG/RTOG 0126.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.5_suppl.375
Abstract: 375 Background: Dose-escalated radiation therapy is standard treatment for patients with prostate cancer. Dose-escalation improves cancer control but also increases the risk of treatment adverse effects. We hypothesized RNA-based tumor gene expression recapitulates normal tissue… read more here.
Keywords: treatment; adverse events; dose escalated; radiation ... See more keywords
Efficacy and toxicity of image-guided intensity-modulated radiation therapy combined with dose-escalated brachytherapy for stage IIB cervical cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.22434
Abstract: Considering internal organ motion and tumor regression, it is controversial to use intensity-modulated radiation therapy (IMRT) in definitive radiotherapy for cervical cancer. In this study, we evaluated the efficacy and toxicity of IMRT combined with… read more here.
Keywords: combined dose; stage iib; cervical cancer; toxicity ... See more keywords
Dosimetric Feasibility Study of Dose Escalated Stereotactic Body Radiation Therapy (SBRT) in Locally Advanced Pancreatic Cancer (LAPC) Patients: It Is Time to Raise the Bar
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.600940
Abstract: Background and Objective To assess the dosimetric feasibility of a stereotactic body radiotherapy (SBRT) dose escalated protocol, with a simultaneous integrated boost (SIB) and a simultaneous integrated protection (SIP) approach, in patients with locally advanced… read more here.
Keywords: ptvsip; dose escalated; dosimetric feasibility; stereotactic body ... See more keywords
Intrafraction Prostate Motion Management During Dose-Escalated Linac-Based Stereotactic Body Radiation Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.883725
Abstract: Background Extreme hypofractionation requires tight planning margins, high dose gradients, and strict adherence to planning criteria in terms of patient positioning and organ motion mitigation. This study reports the first clinical experience worldwide using a… read more here.
Keywords: time; motion; dose escalated; motion management ... See more keywords
Long-Term Outcomes of Dose-Escalated Hypofractionated Radiotherapy in Localized Prostate Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11030435
Abstract: Simple Summary Moderately hypofractionated radiotherapy (HFRT) has been shown to be isoeffective compared to conventional regimens in the treatment of prostate cancer (PCa). In addition, dose-escalation improves biochemical or metastasis control with minimal toxicity, although… read more here.
Keywords: prostate cancer; dose escalated; toxicity; quality life ... See more keywords
Dose Escalation of Oropharyngeal Cancer: Long-Time Follow-Up and Side Effects
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15092580
Abstract: Simple Summary In head and neck cancer, local recurrences are unfortunately common. A more intense local treatment, such as an increased radiation dose to the primary tumour, could potentially prevent some of these recurrencies. Previous… read more here.
Keywords: standard dose; dose escalated; radiotherapy; side effects ... See more keywords
Preoperative Dose-Escalated Intensity-Modulated Radiotherapy (IMRT) and Intraoperative Radiation Therapy (IORT) in Patients with Retroperitoneal Soft-Tissue Sarcoma: Final Results of a Clinical Phase I/II Trial
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15102747
Abstract: Simple Summary Retroperitoneal sarcomas represent a very rare entity. The most common pattern of recurrence and cause of death is local recurrence, and the rates of locoregional recurrences are high even at high-volume centers. In… read more here.
Keywords: dose escalated; soft tissue; trial; iort ... See more keywords