Finerenone Dose–Exposure–Serum Potassium Response Analysis of FIDELIO-DKD Phase III: The Role of Dosing, Titration, and Inclusion Criteria
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacokinetics"
DOI: 10.1007/s40262-021-01083-1
Abstract: Finerenone is a nonsteroidal selective mineralocorticoid receptor antagonist (MRA) that demonstrated efficacy in delaying the progression of chronic kidney disease (CKD) and reducing cardiovascular events in patients with CKD and type 2 diabetes mellitus in… read more here.
Keywords: potassium; response; finerenone dose; fidelio dkd ... See more keywords
Persistent brainwave disruption and cognitive impairment induced by acute sarin surrogate sub-lethal dose exposure.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology"
DOI: 10.1016/j.tox.2021.152787
Abstract: Warfare neurotoxicants such as sarin, soman or VX, are organophosphorus compounds which irreversibly inhibit cholinesterase. High-dose exposure with nerve agents (NA) is known to produce seizure activity and related brain damage, while less is known… read more here.
Keywords: sarin surrogate; sub lethal; exposure; lethal dose ... See more keywords
CdSe Quantum Dots Incurred Hemoglobin RNA Transcription Inhibition in Embryonic Erythroid Precursors and Compromised Embryonic Development in Mice under Low-Dose Exposure
Sign Up to like & getrecommendations! Published in 2018 at "ACS Sustainable Chemistry & Engineering"
DOI: 10.1021/acssuschemeng.7b04581
Abstract: Sustainable development of nanotechnology should comprise maximum benefits and minimum potential risks to the environment and human health. Despite quantum dots (QDs) being widely acknowledged as promising nanomaterials in various application fields, there are still… read more here.
Keywords: transcription; low dose; exposure; quantum dots ... See more keywords
Use of dose–exposure–response relationships in Phase 2 and Phase 3 guselkumab studies to optimize dose selection in psoriasis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.15668
Abstract: Guselkumab is an anti‐interleukin‐23 monoclonal antibody for the treatment of moderate‐to‐severe psoriasis. read more here.
Keywords: phase; exposure response; psoriasis; guselkumab ... See more keywords
Dose–exposure–IGF-I response of once-weekly somapacitan in adults with GH deficiency
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Endocrinology"
DOI: 10.1530/eje-21-1167
Abstract: Objective Growth hormone (GH) replacement therapy in patients with adult growth hormone deficiency (AGHD) is individually titrated due to variable dose–responses among patients. The aim of this study was to provide clinical guidance on dosing… read more here.
Keywords: exposure igf; somapacitan; dose exposure; igf response ... See more keywords
Metagenome Analysis Identifies Microbial Shifts upon Deoxynivalenol Exposure and Post-Exposure Recovery in the Mouse Gut
Sign Up to like & getrecommendations! Published in 2023 at "Toxins"
DOI: 10.3390/toxins15040243
Abstract: Deoxynivalenol (DON) is one of the most prevalent food-associated mycotoxins, and is known to cause a variety of adverse health effects on human and animals. Upon oral exposure, the intestine is the main target organ… read more here.
Keywords: mouse; dose exposure; gut microbiome; exposure ... See more keywords
Chronic Low-dose Exposure to Highly Toxic Gas Phosgene and Its Effect on Peak Expiratory Flow Rate
Sign Up to like & getrecommendations! Published in 2022 at "Indian Journal of Occupational and Environmental Medicine"
DOI: 10.4103/ijoem.ijoem_417_20
Abstract: Introduction: Phosgene is a highly toxic gas causing irritation of the airways and eyes though at high dose exposure. The effect on airways can be assessed by peak expiratory flow rate (PEFR) which is a… read more here.
Keywords: chronic low; phosgene; dose exposure; exposure ... See more keywords