28‐Day Repeated Dose Toxicity and Toxicokinetics Study on Dihydroartemisinin (DHA) in SD Rats
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4738
Abstract: Dihydroartemisinin (DHA) is an effective antimalarial drug with potential antitumor efficacy, yet toxicological information is limited. The present study was designed to evaluate the potential toxicity of oral DHA. DHA was administered orally by gavage… read more here.
Keywords: female rats; toxicity; dihydroartemisinin dha; dha ... See more keywords
Assessment of warfarin algorithms for hospitalized adults: searching for a safe dosing strategy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-019-01902-0
Abstract: This study evaluates three warfarin dosing algorithms (Kimmel, Dawson, High Dose ≥ 2.5 mg) for hospitalized older adults. A random selection of 250 patients with overshoots (INR ≥ 5 after 48 h of hospitalization) and 250 patients without overshoots were accessed… read more here.
Keywords: high dose; warfarin; dose group; algorithms ... See more keywords
Comparison of high- and low-dose 4-factor prothrombin complex concentrate for the emergent reversal of oral Factor Xa inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-021-02412-8
Abstract: Even though there are several reversal strategies available for oral Factor Xa inhibitor associated coagulopathies, 4-factor prothrombin complex concentrate (4F-PCC) is used commonly as the primary reversal agent at many institutions. A dose of 50… read more here.
Keywords: low dose; oral factor; high dose; dose group ... See more keywords
Randomized Study on the Efficacy of Standard Versus Low Roxadustat Dose for Anemia in Patients on Peritoneal Dialysis
Sign Up to like & getrecommendations! Published in 2022 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2021.12.025
Abstract: Introduction We aimed to investigate whether a lower starting dose of roxadustat (∼1–1.4 mg/kg) converted from erythropoiesis-stimulating agent (ESA) could achieve a comparable hemoglobin (Hb) target (≥100 and ≤120 g/l) compared with the standard weight-based… read more here.
Keywords: dose group; peritoneal dialysis; dose; week ... See more keywords
Effect of shenyan xiaobai granule on nephrin and podocin of adriamycin-induced renal injury: A randomised controlled trial.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2019.112104
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE ShenYanXiaoBai granules is a traditional Chinese herbal medicine, It is used widely for the treatment of proteinuria caused by various kidney diseases. AIM OF THE STUDY This study investigated the mechanism of Shenyan… read more here.
Keywords: week; xiaobai granule; shenyan xiaobai; dose group ... See more keywords
Subcutaneous immunoglobulin for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (PATH): a randomised, double-blind, placebo-controlled, phase 3 trial
Sign Up to like & getrecommendations! Published in 2018 at "The Lancet Neurology"
DOI: 10.1016/s1474-4422(17)30378-2
Abstract: BACKGROUND Approximately two-thirds of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) need long-term intravenous immunoglobulin. Subcutaneous immunoglobulin (SCIg) is an alternative option for immunoglobulin delivery, but has not previously been investigated in a large trial… read more here.
Keywords: low dose; treatment; dose group; group ... See more keywords
Early outcomes, associated factors and predictive values of clinical outcomes of tandospirone in generalized anxiety disorder: a post-hoc analysis of a randomized, controlled, multicenter clinical trial
Sign Up to like & getrecommendations! Published in 2023 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2023.2175998
Abstract: Abstract Objective To examine the early outcomes, associated factors and predictive values of clinical outcomes of different tandospirone doses in patients with a generalized anxiety disorder (GAD). Methods This was a posthoc analysis of “a… read more here.
Keywords: dose group; group; early outcomes; high dose ... See more keywords
Efficacy and safety of a novel acetylcholinesterase inhibitor octohydroaminoacridine in mild-to-moderate Alzheimer's disease: a Phase II multicenter randomised controlled trial
Sign Up to like & getrecommendations! Published in 2017 at "Age and Ageing"
DOI: 10.1093/ageing/afx045
Abstract: Background inhibition of acetylcholinesterase (AChE) has been a effective treatment for Alzheimer's disease (AD). Octohydroaminoacridine, a new AChE inhibitor, is a potential treatment for AD. Method we conducted a multicenter, randomised, double blind, placebo-controlled, parallel-group… read more here.
Keywords: alzheimer disease; high dose; dose group; group ... See more keywords
Apixaban in a porcine model of mechanical valve thrombosis in pulmonary position—a pilot study
Sign Up to like & getrecommendations! Published in 2022 at "Interactive Cardiovascular and Thoracic Surgery"
DOI: 10.1093/icvts/ivac070
Abstract: Abstract OBJECTIVES The newest mechanical valves have low thrombogenicity, making them candidates for anticoagulation with a direct oral anticoagulant. While these drugs hold great promise to replace warfarin, clinical trials have been disappointing so far.… read more here.
Keywords: dose group; valve; thrombosis; position ... See more keywords
Amrubicin monotherapy for refractory, relapsed, small cell lung cancer in elderly patients.
Sign Up to like & getrecommendations! Published in 2025 at "Japanese journal of clinical oncology"
DOI: 10.1093/jjco/hyaf140
Abstract: BACKGROUND Amrubicin monotherapy has been used in Japan for patients with refractory, relapsed, small cell lung cancer (SCLC). However, the clinical guidelines do not specify a recommended initial dose for elderly patients. This retrospective study… read more here.
Keywords: dose; amrubicin monotherapy; elderly patients; refractory relapsed ... See more keywords
Dofetilide-Associated QT Prolongation: Total Body Weight Versus Adjusted or Ideal Body Weight for Dosing
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000610
Abstract: Abstract: Dofetilide is an antiarrhythmic drug with dosing based on the Cockcroft–Gault formula using total body weight (TBW). We investigated the impact of calculating dofetilide dose using adjusted body weight (ABW) or ideal body weight… read more here.
Keywords: prolongation; dose group; body weight; body ... See more keywords