Dose Individualisation of Antimicrobials from a Pharmacometric Standpoint: The Current Landscape
Sign Up to like & getrecommendations! Published in 2024 at "Drugs"
DOI: 10.1007/s40265-024-02084-7
Abstract: Successful antimicrobial therapy depends on achieving optimal drug concentrations within individual patients. Inter-patient variability in pharmacokinetics (PK) and differences in pathogen susceptibility (reflected in the minimum inhibitory concentration, [MIC]) necessitate personalised approaches. Dose individualisation strategies… read more here.
Keywords: dose individualisation; individualisation; drug; model ... See more keywords
The remarkable therapeutic potential of response-based dose individualisation in drug trials and patient care.
Sign Up to like & getrecommendations! Published in 2018 at "Drug discovery today"
DOI: 10.1016/j.drudis.2018.04.005
Abstract: The FDA reported that most drugs are effective in only 25-62% of patients. Although many drugs require dose individualisation in clinical practice, dose-finding trials usually aim to identify an optimal dose for the patient population.… read more here.
Keywords: drug; response based; patient care; dose individualisation ... See more keywords