Model-Based Biomarker Selection for Dose Individualization of Tyrosine-Kinase Inhibitors
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DOI: 10.3389/fphar.2020.00316
Abstract: Tyrosine-kinase inhibitors (TKIs) demonstrate high inter-individual variability with respect to safety and efficacy and would therefore benefit from dose or schedule adjustments. This study investigated the efficacy, safety, and economical aspects of alternative dosing options… read more here.
Keywords: kinase inhibitors; model based; biomarker; dose individualization ... See more keywords
State of Art of Dose Individualization to Support tacrolimus drug monitoring: What’s Next?
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DOI: 10.3389/ti.2025.14201
Abstract: Tacrolimus is an immunosuppressant with a narrow therapeutic index and a high intra- and inter-patient variability showing significant challenges in optimal dosing and monitoring. Historically, pre-dose concentration monitoring and simplified area under the curve measurements… read more here.
Keywords: dose individualization; state art; drug monitoring;
Free and Open-Source Posologyr Software for Bayesian Dose Individualization: An Extensive Validation on Simulated Data
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DOI: 10.3390/pharmaceutics14020442
Abstract: Model-informed precision dosing is being increasingly used to improve therapeutic drug monitoring. To meet this need, several tools have been developed, but open-source software remains uncommon. Posologyr is a free and open-source R package developed… read more here.
Keywords: software; open source; dose individualization; posologyr ... See more keywords