Prognostic impact of the cumulative dose and dose intensity of everolimus in patients with pancreatic neuroendocrine tumors
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Medicine"
DOI: 10.1002/cam4.1028
Abstract: The aim of this work is to assess if cumulative dose (CD) and dose intensity (DI) of everolimus may affect survival of advanced pancreatic neuroendocrine tumors (PNETs) patients. One hundred and sixteen patients (62 males… read more here.
Keywords: pancreatic neuroendocrine; group; cumulative dose; dose intensity ... See more keywords
Oncology nurse phone calls halve the risk of reduced dose intensity of immunochemotherapy: results of the randomized FORTIS study in chronic lymphocytic leukemia.
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Hematology"
DOI: 10.1007/s00277-019-03631-z
Abstract: Delivering of > 80% planned relative dose intensity (RDI) of fludarabine-cyclophosphamide-rituximab (FCR) is key to benefit from longer progression free survival (PFS) and survivals in CLL. In this randomized trial, we sought to investigate whether a… read more here.
Keywords: dose intensity; oncology; oncology nurse; risk reduced ... See more keywords
[Chemotherapy for colorectal cancer: Pragmatic assessment of prescription changes and relative dose intensity].
Sign Up to like & getrecommendations! Published in 2017 at "Bulletin du cancer"
DOI: 10.1016/j.bulcan.2017.04.006
Abstract: INTRODUCTION Chemotherapy induced toxicities can generate changes in prescribing and relative dose intensity which have an impact on therapeutic efficacy. METHOD This is a prospective observational study performed in hepato-gastroenterology department for 6 months. All… read more here.
Keywords: colorectal cancer; relative dose; prescription; cancer ... See more keywords
Acute pancreatitis in children with acute lymphoblastic leukemia correlates with L-asparaginase dose intensity
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DOI: 10.1038/s41390-021-01796-w
Abstract: l-Asparaginase (l-Asp) is an important therapeutic for childhood acute lymphoblastic leukemia (ALL). Asparaginase-associated pancreatitis (AAP) is a severe complication of l-Asp related to the dosage. We investigated the incidence of, and risk factors for, AAP… read more here.
Keywords: pancreatitis; lymphoblastic leukemia; acute lymphoblastic; dose intensity ... See more keywords
Impact of relative dose intensity of trabectedin with pegfilgrastim support: a single-centre retrospective study.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemotherapy"
DOI: 10.1080/1120009x.2022.2164116
Abstract: Relative dose intensity (RDI) has been associated with improved survival in patients with advanced solid tumours. However, there is no evidence regarding RDI in patients under long-term treatment with trabectedin for adult advanced soft tissue… read more here.
Keywords: dose intensity; relative dose; trabectedin; pegfilgrastim ... See more keywords
Ideal dose intensity of R-CHOP in diffuse large B-cell lymphoma
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DOI: 10.1080/14737140.2022.2071262
Abstract: ABSTRACT Introduction The standard of care for diffuse large B-cell lymphoma (DLBCL) is rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). However, its ideal dose intensity varies among cases. Areas covered This review provides the latest… read more here.
Keywords: lymphoma; chop; dose intensity; dlbcl ... See more keywords
Role of Cisplatin Dose Intensity and TPMT Variation in the Development of Hearing Loss in Children
Sign Up to like & getrecommendations! Published in 2023 at "Therapeutic Drug Monitoring"
DOI: 10.1097/ftd.0000000000001085
Abstract: Background: Cisplatin, widely used in the treatment of solid tumors, causes permanent hearing loss in more than 60% of treated children. Previous studies have implicated several clinical factors in the development of ototoxicity, including cumulative… read more here.
Keywords: cisplatin; dose intensity; cisplatin dose; hearing loss ... See more keywords
Dose modification and dose intensity during treatment with pirfenidone: analysis of pooled data from three multinational phase III trials
Sign Up to like & getrecommendations! Published in 2018 at "BMJ Open Respiratory Research"
DOI: 10.1136/bmjresp-2018-000323
Abstract: Introduction Temporary dose modifications, such as reductions or interruptions, may allow patients to better manage adverse events (AEs) associated with pirfenidone use and continue treatment for idiopathic pulmonary fibrosis (IPF). However, the impact of such… read more here.
Keywords: analysis; treatment; treatment pirfenidone; dose intensity ... See more keywords
Dose Delays, Dose Reductions, and Relative Total Dose Intensity in Patients With Advanced Cancer Who Exercised During Neoadjuvant Chemotherapy Treatment
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DOI: 10.1177/15347354231168368
Abstract: Background: When it comes to chemotherapy, maintaining the dose and schedule of treatment are of vital importance, as clinical evidence suggests that dose intensity is associated with optimal treatment outcomes for various tumors. Yet, reduced… read more here.
Keywords: dose intensity; dose delays; patients advanced; chemotherapy ... See more keywords
Reduced-dose-intensity therapy for pediatric lymphoblastic leukemia: long-term results of the Recife RELLA05 pilot study.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2019004215
Abstract: Treatment-related mortality is common among children with acute lymphoblastic leukemia (ALL) treated in poor-resource settings. We applied a simplified flow-cytometric assay to identify patients with precursor B-cell ALL (B-ALL) at very low risk (VLR) of… read more here.
Keywords: reduced dose; treatment; lymphoblastic leukemia; dose intensity ... See more keywords
Carfilzomib Dosing Patterns and Time to Next Treatment Among Adult Patients with Multiple Myeloma Treated in the US Community Oncology Setting
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DOI: 10.1182/blood.v130.suppl_1.3433.3433
Abstract: Introduction Carfilzomib (Kyprolis; K) is a selective 20S proteasome inhibitor indicated for the treatment of patients with relapsed or refractory multiple myeloma (MM). The indications for K in the US package insert (label) and dosing… read more here.
Keywords: label; per label; treatment; dose intensity ... See more keywords