Ethnic‐specific predictors of neurotoxicity among patients with pediatric acute lymphoblastic leukemia after high‐dose methotrexate
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DOI: 10.1002/cncr.34646
Abstract: High‐dose methotrexate (HD‐MTX; 5000 mg/m2) is an important component of curative therapy in many treatment regimens for high‐risk pediatric acute lymphoblastic leukemia (ALL). However, methotrexate therapy can result in dose‐limiting neurotoxicity, which may disproportionately affect… read more here.
Keywords: pediatric acute; dose methotrexate; high dose; lymphoblastic leukemia ... See more keywords
Concomitant use of low‐dose methotrexate and NSAIDs and the risk of serious adverse events among patients with rheumatoid arthritis
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DOI: 10.1002/pds.4555
Abstract: Case reports and pharmacokinetic studies have suggested that concomitant use of low‐dose methotrexate and nonsteroidal anti‐inflammatory drugs (NSAIDs) may be associated with increased risk of methotrexate toxicity. This study aimed to investigate the risk of… read more here.
Keywords: low dose; methotrexate; use low; dose methotrexate ... See more keywords
Acute kidney injury, agranulocytosis, drug-induced liver injury, and posterior reversible encephalopathy syndrome caused by high-dose methotrexate—possible role of low activity ABC and SLC drug transporters
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DOI: 10.1007/s00228-018-2485-6
Abstract: Methotrexate (MTX) is an essential drug in the treatment of acute lymphoblastic leukemia (ALL). High-dose methotrexate (HD-MTX) administration (> 1 g/m) can lead to its tubular precipitation, leading to acute kidney injury (AKI) and other… read more here.
Keywords: high dose; drug; mtx; dose methotrexate ... See more keywords
Ambulatory high-dose methotrexate administration as central nervous system prophylaxis in patients with aggressive lymphoma
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DOI: 10.1007/s00277-020-04341-7
Abstract: High-dose methotrexate (HD-MTX) at 3 g/m2 is one of the strategies for central nervous system (CNS) prophylaxis in the first-line treatment of aggressive lymphomas, especially in diffuse large B cell lymphoma patients with high-risk CNS-International… read more here.
Keywords: administration; high dose; nervous system; central nervous ... See more keywords
Pharmacokinetics and pharmacogenetics of high-dose methotrexate in Chinese adult patients with non-Hodgkin lymphoma: a population analysis
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DOI: 10.1007/s00280-020-04058-4
Abstract: Purpose High-dose methotrexate (HD-MTX) is widely used in the treatment of non-Hodgkin lymphoma (NHL), but the pharmacokinetic properties of HD-MTX in Chinese adult patients with NHL have not yet been established through an approach that… read more here.
Keywords: adult; chinese adult; high dose; non hodgkin ... See more keywords
Comparison of alternative βhCG follow-up protocols after single-dose methotrexate therapy for tubal ectopic pregnancy
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DOI: 10.1007/s00404-017-4527-1
Abstract: PurposeTo evaluate the performances of five different βhCG follow-up protocols after single-dose methotrexate therapy for tubal ectopic pregnancy (EP).MethodsData of patients who received single-dose methotrexate therapy for tubal EP at a university hospital between January… read more here.
Keywords: methotrexate; follow protocols; hcg decrease; dose methotrexate ... See more keywords
Early predictive factors of single dose methotrexate outcome in patients with ectopic pregnancy
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DOI: 10.1007/s00404-019-05255-0
Abstract: We read with great interest the comment of Levin et al. regarding our article recently published in Archives of Gynecology and Obstetrics [1]. In their letter, the authors suggest that the dosage we used for… read more here.
Keywords: treatment; success; mtx; dose methotrexate ... See more keywords
High-dose methotrexate and rituximab induction regimen in immunocompetent patients with primary CNS lymphoma: a retrospective single-center study of survival predictors
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DOI: 10.1007/s11060-022-04004-9
Abstract: Primary Central Nervous System Lymphoma (PCNSL) is an aggressive tumor that is confined to the CNS. Although the provision of high-dose methotrexate (HD-MTX) has remarkably improved outcomes in PCNSL patients, the optimal treatment regimens and… read more here.
Keywords: immunocompetent patients; study; induction; rituximab ... See more keywords
Various BhCG monitoring protocols for predicting the success of single-dose methotrexate in the treatment of ectopic pregnancy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Obstetrics and Gynaecology"
DOI: 10.1080/01443615.2019.1575344
Abstract: Abstract We investigated various monitoring protocols on the success of methotrexate therapy in patients with tubal ectopic pregnancy. The data from patients who received single-dose methotrexate therapy as their first-line treatment was reviewed. The Beta-human… read more here.
Keywords: methotrexate; success; dose methotrexate; single dose ... See more keywords
High dose methotrexate containing regimen in pediatric non-metastatic extremity osteosarcoma patients: experience from a tertiary cancer center in India.
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DOI: 10.1080/08880018.2021.1963021
Abstract: Methotrexate containing chemotherapy is less commonly used for treatment of osteosarcoma in resource limited settings. We present our experience with the administration of high dose methotrexate (HDMTX) containing chemotherapy over a period of three years.… read more here.
Keywords: chemotherapy; methotrexate; high dose; dose methotrexate ... See more keywords
Low-dose methotrexate enhances cycling of highly anaplastic cancer cells
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DOI: 10.1080/15384101.2016.1252883
Abstract: ABSTRACT We previously showed that cellular RedOx state governs the G1-S transition of AH130 hepatoma, a tumor spontaneously reprogrammed to the embryonic stem cell stage. This transition is impaired when the mithocondrial electron transport system… read more here.
Keywords: low dose; transition; dose methotrexate; mtx ... See more keywords