A two-stage Bayesian adaptive design for minimum effective dose (MinED)-based dosing-finding trials.
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DOI: 10.1016/j.cct.2021.106504
Abstract: Conventional phase I designs for finding a phase II recommended dose (P2RD) based on toxicity alone is problematic because the maximum tolerated dose (MTD) is not necessarily the optimal dose. Instead, recently attention has been… read more here.
Keywords: two stage; dose mined; minimum effective; effective dose ... See more keywords