High-dose naloxone, an experimental tool uncovering latent sensitisation: pharmacokinetics in humans.
Sign Up to like & getrecommendations! Published in 2019 at "British journal of anaesthesia"
DOI: 10.1016/j.bja.2018.12.007
Abstract: BACKGROUND Naloxone, an opioid receptor antagonist, is used as a pharmacological tool to detect tonic endogenous activation of opioid receptors in experimental pain models. We describe a pharmacokinetic model linking naloxone pharmacokinetics to its main… read more here.
Keywords: infusion; naloxone experimental; dose naloxone; model ... See more keywords
Naloxone reversal of clonidine toxicity: dose, dose, dose
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DOI: 10.1080/15563650.2018.1450986
Abstract: Abstract Context: Following clonidine ingestion, naloxone is seldom administered as it is considered ineffective in reversing somnolence, bradycardia, or hypotension. However, this conclusion has been based on administration of small doses (2 mg or less) of… read more here.
Keywords: administration; hypotension; dose naloxone; clonidine toxicity ... See more keywords
Low dose naloxone for pruritus in systemic sclerosis
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DOI: 10.1097/md.0000000000028653
Abstract: Abstract Rationale: Pruritus is a common symptom in patients with systemic sclerosis and has a tremendous effect on the quality of life. Nevertheless, current therapeutic options are limited. The pathogenesis of pruritus in systemic sclerosis… read more here.
Keywords: pruritus; dose naloxone; pruritus systemic; low dose ... See more keywords