Utility of Naltrexone Treatment for Chronic Inflammatory Dermatologic Conditions: A Systematic Review
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Dermatology"
DOI: 10.1001/jamadermatol.2018.4093
Abstract: Importance Dermatology is encountering increasing rates of autoimmune disease manifesting in primary skin conditions that are difficult to treat without a risk of immunosuppression. Naltrexone is an orally active opioid antagonist that influences a variety… read more here.
Keywords: low dose; dermatology; treatment; dose naltrexone ... See more keywords
Low-dose naltrexone inhibits the epithelial-mesenchymal transition of cervical cancer cells in vitro and effects indirectly on tumor-associated macrophages in vivo.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106718
Abstract: The metastasis of cervical cancer has always been a clinical challenge. We investigated the effects of low-dose naltrexone (LDN) on the epithelial mesenchymal transition of cervical cancer cells in vitro as well as its influence… read more here.
Keywords: mesenchymal transition; low dose; dose naltrexone; cervical cancer ... See more keywords
Low-Dose Naltrexone reduces symptoms in Stiff-Person Syndrome.
Sign Up to like & getrecommendations! Published in 2020 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2019.109546
Abstract: Stiff-Person Syndrome (SPS) is a rare neurologic disorder characterized by severe and progressively worsening muscle stiffness and rigidity. SPS can be very painful due to unpredictable muscle spasms which can be triggered by various stimuli,… read more here.
Keywords: person syndrome; low dose; naltrexone reduces; dose naltrexone ... See more keywords
Low-Dose Naltrexone for the Treatment of Fibromyalgia: Investigation of Dose-Response Relationships.
Sign Up to like & getrecommendations! Published in 2020 at "Pain medicine"
DOI: 10.1093/pm/pnaa001
Abstract: OBJECTIVE This study explores dose-response relationships when treating fibromyalgia with low-dose naltrexone. DESIGN A single-blinded clinical trial was carried out using the "up-and-down" method. SUBJECTS Subjects included women with a diagnosis of fibromyalgia aged 18-60 years… read more here.
Keywords: dose response; response relationships; low dose; dose naltrexone ... See more keywords
Effects of Varenicline Alone and in Combination With Low-dose Naltrexone on Alcohol-primed Smoking in Heavy-drinking Tobacco Users: A Preliminary Laboratory Study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Addiction Medicine"
DOI: 10.1097/adm.0000000000000392
Abstract: Objectives: Heavy-drinking tobacco users are less likely to successfully quit smoking than their moderate-drinking counterparts, even when they are prescribed smoking cessation medication. One strategy for improving treatment outcomes in this subgroup of tobacco users… read more here.
Keywords: drinking; tobacco; low dose; dose naltrexone ... See more keywords
Efficacy and safety of low‐dose naltrexone in painful diabetic neuropathy: A randomized, double‐blind, active‐control, crossover clinical trial
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Diabetes"
DOI: 10.1111/1753-0407.13202
Abstract: There is a need for newer therapies for chronic painful diabetic neuropathy as the existing drugs have their own limitations. Clinical trials on low‐dose naltrexone (1‐5 mg/d) showed efficacy and safety in certain chronic painful conditions,… read more here.
Keywords: low dose; painful diabetic; efficacy safety; diabetic neuropathy ... See more keywords
Study protocol for a randomised, double-blinded, placebo-controlled phase III trial examining the add-on efficacy, cost–utility and neurobiological effects of low-dose naltrexone (LDN) in patients with fibromyalgia (INNOVA study)
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Open"
DOI: 10.1136/bmjopen-2021-055351
Abstract: Introduction There is evidence that low-dose naltrexone (LDN; read more here.
Keywords: innova study; trial; naltrexone ldn; dose naltrexone ... See more keywords
Low dose naltrexone in multiple sclerosis: Effects on medication use. A quasi-experimental study
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0187423
Abstract: Low dose naltrexone (LDN) has become a popular off-label therapy for multiple sclerosis (MS). A few small, randomized studies indicate that LDN may have beneficial effects in MS and other autoimmune diseases. If proven efficacious,… read more here.
Keywords: low dose; dose naltrexone; quasi experimental; multiple sclerosis ... See more keywords
Reported Benefits of Low-Dose Naltrexone Appear to Be Independent of the Endogenous Opioid System Involving Proopiomelanocortin Neurons and β-Endorphin
Sign Up to like & getrecommendations! Published in 2021 at "eNeuro"
DOI: 10.1523/eneuro.0087-21.2021
Abstract: Abstract Naltrexone is an opioid receptor antagonist approved for the treatment of alcohol and opioid use disorders at doses of 50–150 mg/d. Naltrexone has also been prescribed at much lower doses (3–6 mg/d) for the off-label treatment… read more here.
Keywords: endogenous opioid; opioid; pomc neurons; low dose ... See more keywords
The Safety and Efficacy of Low-Dose Naltrexone in Patients with Fibromyalgia: A Systematic Review
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Pain Research"
DOI: 10.2147/jpr.s395457
Abstract: Abstract Fibromyalgia (FM) is a chronic pain sensitivity syndrome characterized by diffuse musculoskeletal pain and many other systemic manifestations. Low-dose naltrexone (LDN) has been increasingly used as an off-label treatment option in FM. However, current… read more here.
Keywords: safety; review; safety efficacy; efficacy ... See more keywords
Low-dose naltrexone, an opioid-receptor antagonist, is a broad-spectrum analgesic: a retrospective cohort study.
Sign Up to like & getrecommendations! Published in 2022 at "Pain management"
DOI: 10.2217/pmt-2021-0122
Abstract: Aim: To evaluate the use of low-dose naltrexone (LDN) as a broad-spectrum analgesic. Methods: Retrospective cohort study from a single pain management practice using data from 2014 to 2020. Thirty-six patients using LDN for ≥2 months were… read more here.
Keywords: spectrum analgesic; retrospective cohort; low dose; pain ... See more keywords