Dose Number as a Tool to Guide Lead Optimization for Orally Bioavailable Compounds in Drug Discovery.
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DOI: 10.1021/acs.jmedchem.1c01687
Abstract: Small molecule developability challenges have been well documented over the last two decades. One of these critical developability parameters is aqueous solubility. In general, more soluble compounds have improved oral absorption. While enabling formulation technologies… read more here.
Keywords: number tool; dose number; tool guide; discovery ... See more keywords
Assessment of the Relationship Between Dose and Number of Effective Used Drugs on on QT Interval in Patients with Lupus
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DOI: 10.5812/semj.83710
Abstract: Background: Systemic lupus erythematosus is an autoimmune and multi-organ disease. Cardiovascular involvement is one of most important causes of death in these patients. In some studies, it has been observed that the prolongation of the… read more here.
Keywords: relationship dose; qtc interval; dose number; assessment relationship ... See more keywords