DOP15 Results of a pragmatic multicentred randomised controlled trial investigating the use of personalised golimumab dosing in Ulcerative Colitis: the GOAL-ARC study (GLM dose Optimisation to Adequate Levels to Achieve Response in Colitis)
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjad212.0055
Abstract: Ulcerative Colitis (UC) is a chronic inflammatory bowel disease (IBD) often leading to impaired quality of life in affected patients. Current treatment modalities include anti-tumour necrosis factor (anti-TNF) monoclonal antibodies including infliximab, adalimumab and golimumab… read more here.
Keywords: treatment; glm; dose optimisation; response ... See more keywords
Dose optimisation and scarce resource allocation: two sides of the same coin
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DOI: 10.1136/bmjopen-2022-063436
Abstract: Objective A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines. Summary of key data The vast majority of drug… read more here.
Keywords: optimisation; dose optimisation; scarce resource; resource allocation ... See more keywords
Dose Optimisation of Posaconazole and Therapeutic Drug Monitoring in Pediatric Patients
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DOI: 10.3389/fphar.2022.833303
Abstract: Experience in the clinical use of posaconazole (PCZ) in pediatric patients is limited, and no specific dose recommendations exist. This study aimed to investigate an appropriate dosing regimen, and assess the exposure-response relationships of PCZ… read more here.
Keywords: dose optimisation; pcz; pcz concentrations; optimisation posaconazole ... See more keywords