Barriers to CT Dose Optimization: The Challenge of Organizational Change.
Sign Up to like & getrecommendations! Published in 2020 at "Academic radiology"
DOI: 10.1016/j.acra.2020.02.016
Abstract: BACKGROUND The use of diagnostic imaging with computed tomography (CT) has risen significantly, increasing cumulative life-time exposure to ionizing radiation for patients and raising concerns about increased cancer risk. Lowering the doses would reduce concerns… read more here.
Keywords: change; radiation; dose optimization; barriers dose ... See more keywords
Model-based Voriconazole Dose Optimization in Chinese Adult Patients With Hematologic Malignancies.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2019.04.027
Abstract: PURPOSE The objective of this study was to characterize the population pharmacokinetics of voriconazole and to identify factors that significantly affect pharmacokinetic parameters and to further investigate optimal dosage regimens in Chinese adult patients with… read more here.
Keywords: chinese adult; patients hematologic; hematologic malignancies; dose optimization ... See more keywords
111. Dose optimization in mammographic screening: results from ten years invigilation
Sign Up to like & getrecommendations! Published in 2018 at "Physica Medica"
DOI: 10.1016/j.ejmp.2018.04.121
Abstract: Purpose Mammographic screening represents one of the most significant medical expose to radiation for women. The method proposed from European Reference Organisation for Quality Assured Breast Screening and Diagnostic Services (EUREF) evaluate average glandular dose… read more here.
Keywords: 111 dose; mammographic screening; optimization mammographic; screening results ... See more keywords
Spark Architecture for deep learning-based dose optimization in medical imaging
Sign Up to like & getrecommendations! Published in 2020 at "Informatics in Medicine Unlocked"
DOI: 10.1016/j.imu.2020.100335
Abstract: Abstract Background and objectives Deep Learning (DL) and Machine Learning (ML) have brought several breakthroughs to biomedical image analysis by making available more consistent and robust tools for the identification, classification, reconstruction, denoising, quantification, and… read more here.
Keywords: image; low dose; pipeline; optimization ... See more keywords
Patient dose optimization for computed radiography using physical and observer-based measurements as image quality metrics
Sign Up to like & getrecommendations! Published in 2020 at "Radiation Physics and Chemistry"
DOI: 10.1016/j.radphyschem.2020.108768
Abstract: Abstract Radiation protection of patients undergoing diagnostic x-ray examinations requires practical evaluation of doses and image quality under clinical conditions. On this subject, optimization of the dose-image quality relationship plays key role in order to… read more here.
Keywords: dose optimization; image; image quality; patient dose ... See more keywords
Pharmacokinetics/Pharmacodynamics of β-Lactams and Therapeutic Drug Monitoring: From Theory to Practical Issues in the Intensive Care Unit.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in respiratory and critical care medicine"
DOI: 10.1055/s-0039-1693498
Abstract: Despite therapeutic advances over recent decades, the mortality rate for sepsis and septic shock is still approximately 25% worldwide. Early administration of appropriate intravenous antibiotics in the right dose is one of the cornerstones of… read more here.
Keywords: drug; therapeutic drug; care; drug monitoring ... See more keywords
Strategies for clinical dose optimization of T cell-engaging therapies in oncology
Sign Up to like & getrecommendations! Published in 2023 at "mAbs"
DOI: 10.1080/19420862.2023.2181016
Abstract: ABSTRACT Innovative approaches in the design of T cell-engaging (TCE) molecules are ushering in a new wave of promising immunotherapies for the treatment of cancer. Their mechanism of action, which generates an in trans interaction… read more here.
Keywords: oncology; dose optimization; clinical dose; cell engaging ... See more keywords
Spatial frequency performance limitations of radiation dose optimization and beam positioning.
Sign Up to like & getrecommendations! Published in 2018 at "Physics in medicine and biology"
DOI: 10.1088/1361-6560/aac501
Abstract: The flexibility and sophistication of modern radiotherapy treatment planning and delivery methods have advanced techniques to improve the therapeutic ratio. Contemporary dose optimization and calculation algorithms facilitate radiotherapy plans which closely conform the three-dimensional dose… read more here.
Keywords: radiation dose; delivery; optimization; spatial frequency ... See more keywords
Swapping Versus Dose Optimization in Patients Losing Response to Adalimumab With Adequate Drug Levels.
Sign Up to like & getrecommendations! Published in 2021 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izab158
Abstract: BACKGROUND In cases of loss of response due to mechanistic failure under antitumor necrosis factor agents, it is recommended to switch to another class of biologics. Two different strategies were compared in patients with inflammatory… read more here.
Keywords: trough levels; response; loss response; group ... See more keywords
Abstract 5063: Optimizing benefit/risk in oncology: Review of post marketing dose optimization
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5063
Abstract: Introduction: Molecularly targeted (MTAs) and immune-oncology (IO) agents are more selective with wider therapeutic window than cytotoxic agents resulting in maximal activity at doses < MTD. However, these agents commonly selected the MTD (or highest… read more here.
Keywords: oncology; safety; dose; efficacy ... See more keywords
Tacrolimus Dose Optimization Strategy for Refractory Ulcerative Colitis Based on the Cytochrome P450 3A5 Polymorphism Prediction Using Trough Concentration after 24 Hours
Sign Up to like & getrecommendations! Published in 2018 at "Digestion"
DOI: 10.1159/000484227
Abstract: Background: In the tacrolimus treatment for refractory ulcerative colitis (UC), dose adjustment is necessary because the required doses to keep appropriate drug concentrations are significantly different among individuals. Cytochrome P450 (CYP) 3A5 polymorphism affects tacrolimus… read more here.
Keywords: optimization strategy; cyp3a5 polymorphism; trough concentration; dose optimization ... See more keywords