Assessment of the 4‐week repeated‐dose oral toxicity and genotoxicity of GHX02
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3902
Abstract: Herbal medicines are widely utilized for disease prevention and health promotion. GHX02 consists of mixtures including Gwaruin (Trichosanthes kirilowii), Haengin (Prunus armeniaca), Hwangryeon (Coptis japonica) and Hwangkeum (Scutellaria baicalensis). It has been purported to have… read more here.
Keywords: study; toxicity; dose oral; repeated dose ... See more keywords
An evaluation of the genotoxicity and 90‐day repeated dose oral toxicity in rats of Porphyridium purpureum
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4665
Abstract: Interest in microalgae products for use in food is increasing, as demands for sustainable and cost‐effective food choices grow due to the escalating global population and increase in climate‐related struggles with agriculture. Toxicological assessments of… read more here.
Keywords: repeated dose; oral toxicity; dose oral; day repeated ... See more keywords
Preclinical study of the long‐range safety and anti‐inflammatory effects of high‐dose oral meglumine
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28492
Abstract: Meglumine is a methylamino derivative of sorbitol that is an approved drug excipient. Recent preclinical studies suggest that administration of high‐dose oral meglumine can exert beneficial medicinal effects to treat diabetes, obesity, and fatty liver… read more here.
Keywords: anti inflammatory; meglumine; high dose; dose oral ... See more keywords
Use of High-Dose Oral Valacyclovir During an Intravenous Acyclovir Shortage: A Retrospective Analysis of Tolerability and Drug Shortage Management
Sign Up to like & getrecommendations! Published in 2017 at "Infectious Diseases and Therapy"
DOI: 10.1007/s40121-017-0157-y
Abstract: IntroductionIn late 2011, a shortage of IV acyclovir led to the need to empirically substitute high-dose oral valacyclovir (HDVA) to conserve IV acyclovir for patients with confirmed herpes simplex virus (HSV) meningitis or encephalitis. This… read more here.
Keywords: hdva; high dose; management; dose oral ... See more keywords
Effect of high‐dose oral multivitamins and minerals in participants not treated with statins in the randomized Trial to Assess Chelation Therapy (TACT)
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DOI: 10.1016/j.ahj.2017.09.002
Abstract: Importance In a prespecified subgroup analysis of participants not on statin therapy at baseline in the TACT, a high‐dose complex oral multivitamins and multimineral regimen was found to have a large unexpected benefit compared with… read more here.
Keywords: tact; high dose; end point; dose oral ... See more keywords
Kawasaki Disease Triggering an Episode of Psoriasis - a Case Report.
Sign Up to like & getrecommendations! Published in 2022 at "Klinische Padiatrie"
DOI: 10.1055/a-1885-3140
Abstract: Kawasaki disease (KD) is an acute systemic inflammatory illness causing vasculitis. A diffuse polymorphous rash is one of the predominant features of patients presenting with KD. This rash can have a morbilliform, urticarial, micropustular, or… read more here.
Keywords: dose oral; kawasaki disease; disease triggering; case ... See more keywords
O04 Pharmacological efficacy of low-dose oral minoxidil–finasteride combination for hair growth and stability in male androgenetic alopecia: a 12-month retrospective service evaluation
Sign Up to like & getrecommendations! Published in 2025 at "British Journal of Dermatology"
DOI: 10.1093/bjd/ljaf085.019
Abstract: Androgenetic alopecia (AA) is characterized by progressive miniaturization of scalp follicles mediated by dihydrotestosterone. Conventional treatments include oral finasteride (a type II 5α-reductase inhibitor) and topical minoxidil, but topical regimens can be limited by application… read more here.
Keywords: low dose; dose oral; oral minoxidil; minoxidil ... See more keywords
Long-Term Taste Impairment after Intensity-Modulated Radiotherapy to Treat Head-and-Neck Cancer: Correlations with Glossectomy and the Mean Radiation Dose to the Oral Cavity.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical senses"
DOI: 10.1093/chemse/bjz018
Abstract: We explored the effects of various parameters on taste impairments (TIs) in head-and-neck (H&N) cancer patients receiving intensity-modulated radiotherapy (IMRT). From January 2014 to September 2017, 88 H&N cancer patients subjected to curative or postoperative… read more here.
Keywords: radiation dose; long term; mean radiation; dose oral ... See more keywords
Changes in serum endogenous estrogen concentrations are mediators of the effect of low-dose oral estradiol on vasomotor symptoms
Sign Up to like & getrecommendations! Published in 2022 at "Menopause"
DOI: 10.1097/gme.0000000000002026
Abstract: Abstract Objectives The aim of this study was to quantify changes in serum total estradiol (E2) and estrone (E1) concentrations with initiation of low-dose oral estradiol treatment and evaluate whether changes in concentrations mediate the… read more here.
Keywords: dose oral; effect; estradiol; oral estradiol ... See more keywords
High-Dose Oral Posaconazole for the Treatment of Recalcitrant Fungal Keratitis.
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DOI: 10.1097/ico.0000000000002832
Abstract: PURPOSE To report the successful treatment of 3 cases of recalcitrant fungal keratitis (FK) with high-dose oral posaconazole. METHODS This is a series of 3 patients from a single academic center with a culture-positive FK… read more here.
Keywords: oral posaconazole; recalcitrant fungal; treatment; dose oral ... See more keywords
Metronidazole-Resistant Trichomoniasis: Beneficial Pharmacodynamic Relationship With High-Dose Oral Tinidazole and Vaginal Paromomycin Combination Therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Sexually Transmitted Diseases"
DOI: 10.1097/olq.0000000000000903
Abstract: Metronidazole-resistant trichomoniasis is an uncommon condition that presents significant therapeutic challenges. Combination therapy with high-dose oral tinidazole and vaginal paromomycin cream has been uniformly successful. We present a case report of a patient who responded… read more here.
Keywords: combination therapy; oral tinidazole; dose oral; high dose ... See more keywords