Pharmacokinetics of the Multi‐kinase Inhibitor Pexidartinib: Mass Balance and Dose Proportionality
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DOI: 10.1002/cpdd.1186
Abstract: Pexidartinib is an oral small‐molecule tyrosine kinase inhibitor that selectively targets colony‐stimulating factor 1 receptor. Two phase 1 single‐center trials were conducted in healthy subjects to determine the absorption, distribution, metabolism, and excretion of pexidartinib… read more here.
Keywords: kinase inhibitor; pexidartinib; mass balance; dose proportionality ... See more keywords
Evaluation of Pharmacokinetics and Dose Proportionality of Diazepam After Intranasal Administration of NRL‐1 to Healthy Volunteers
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DOI: 10.1002/cpdd.767
Abstract: NRL‐1 is a novel intranasal formulation of diazepam that is being evaluated as rescue medication in patients with epilepsy who experience bouts of increased seizure activity despite stable regimens of antiepileptic drugs. This phase 1,… read more here.
Keywords: administration; time; dose proportionality; concentration ... See more keywords
Meta‐Analysis of Noncompartmental Pharmacokinetic Parameters of Ertugliflozin to Evaluate Dose Proportionality and UGT1A9 Polymorphism Effect on Exposure
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DOI: 10.1002/jcph.1866
Abstract: Ertugliflozin, a sodium‐glucose cotransporter 2 inhibitor, is primarily metabolized via glucuronidation by the uridine 5′‐diphospho‐glucuronosyltransferase (UGT) isoform UGT1A9. This noncompartmental meta‐analysis of ertugliflozin pharmacokinetics evaluated the relationship between ertugliflozin exposure and dose, and the effect… read more here.
Keywords: exposure; dose proportionality; ertugliflozin; ertugliflozin auc ... See more keywords
Bioavailability and dose proportionality of a highly lipophilic phenolic antioxidant
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DOI: 10.1080/00498254.2025.2465237
Abstract: Abstract IBP (2,6-diisobornyl-4-methylphenol) is a camphene derivative with unique pharmacological properties and low toxicity. It exhibits pronounced antioxidant and membrane-protective effects, making it a promising cardio- and neuroprotector. The aim of the study was investigating… read more here.
Keywords: oral administration; bioavailability dose; dose proportionality; administration ... See more keywords
Pharmacokinetics and Dose Proportionality Study of a Novel Antiparkinsonian Agent, a 1H-1,2,4-Triazol-3-ylthio-conjugate of Prottremine
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DOI: 10.3390/molecules29184498
Abstract: The novel antiparkinsonian agent PA-96 is the focus of our research. PA-96 supported the survival of cultured naïve dopamine neurons, alleviated motor deficits in MPTP and haloperidol-based mice models of Parkinson’s disease, and increased the… read more here.
Keywords: agent; dose proportionality; novel antiparkinsonian; antiparkinsonian agent ... See more keywords