DROID: Dose-ranging approach to optimizing dose in oncology drug development.
Sign Up to like & getrecommendations! Published in 2022 at "Biometrics"
DOI: 10.1111/biom.13840
Abstract: In the era of targeted therapy, there has been increasing concern about the development of oncology drugs based on the "more is better" paradigm, developed decades ago for chemotherapy. Recently, the US Food and Drug… read more here.
Keywords: oncology; oncology drugs; dose ranging; development ... See more keywords
Dose-Ranging and Cohort-Expansion Study of Monalizumab (IPH2201) in Patients with Advanced Gynecologic Malignancies: A Trial of the Canadian Cancer Trials Group (CCTG): IND221
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-19-0298
Abstract: Purpose: Monalizumab binds CD94/NKG2A, preventing HLA-E inhibition of tumor lymphocytes. A dose-ranging/cohort expansion trial of monalizumab for recurrent gynecologic malignancies was conducted to determine the recommended phase II dose (RP2D) and to explore clinical activity,… read more here.
Keywords: part; ranging cohort; dose ranging; cohort expansion ... See more keywords
Interim analysis (IA) of OPTIC: A dose-ranging study of three ponatinib (PON) starting doses.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.7502
Abstract: 7502Background: In PACE (NCT01207440) heavily pretreated patients (pts) with chronic-phase CML (CP-CML) had deep, lasting responses to PON; long-term follow-up showed increasing rates of arterial o... read more here.
Keywords: dose ranging; analysis optic; interim analysis; ranging study ... See more keywords
Dose-ranging study of an orlistat tablet formulation.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of clinical pharmacology and therapeutics"
DOI: 10.5414/cp203191
Abstract: OBJECTIVE Examine inhibition of dietary fat absorption with orlistat tablets (24, 36, 48, 72, and 144 mg) vs. 60-mg orlistat capsule. MATERIALS AND METHODS 83 overweight/obese subjects randomized to 1 of 6 open-label treatments. Pre- vs.… read more here.
Keywords: fecal fat; dose ranging; orlistat tablet; study orlistat ... See more keywords