Dose rationale and pharmacokinetics of dexmedetomidine in mechanically ventilated new-borns: impact of design optimisation
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DOI: 10.1007/s00228-019-02708-y
Abstract: PurposeThere is a need for alternative analgosedatives such as dexmedetomidine in neonates. Given the ethical and practical difficulties, protocol design for clinical trials in neonates should be carefully considered before implementation. Our objective was to… read more here.
Keywords: dose rationale; mechanically ventilated; dexmedetomidine mechanically; optimisation ... See more keywords
Model-Informed Repurposing of Medicines for SARS-CoV-2: Extrapolation of Antiviral Activity and Dose Rationale for Paediatric Patients
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DOI: 10.3390/pharmaceutics13081299
Abstract: Repurposing of remdesivir and other drugs with potential antiviral activity has been the basis of numerous clinical trials aimed at SARS-CoV-2 infection in adults. However, expeditiously designed trials without careful consideration of dose rationale have… read more here.
Keywords: dose rationale; antiviral activity; target; model ... See more keywords